Scientist
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Job Location:
Pleasanton, CA - USA
Monthly Salary:
Not Disclosed
Posted on:
5 days ago
Vacancies:
1 Vacancy
Job Summary
Onsite Requirement: This is an onsite laboratory role. Remote or hybrid arrangements are not permitted due to the nature of the work.
Position Overview
The Scientist II will perform hands-on molecular laboratory work to support the design optimization and
development of qPCR and digital PCR (dPCR) assays for Roche Diagnostics advanced molecular
platforms. This role is classified as laboratory-based requiring routine work with chemical reagents and
human biological materials in a BSL-2 environment.
The individual in this role must be able to perform all essential functions listed below with or without
reasonable accommodation in accordance with ADA and California FEHA guidelines.
Key Responsibilities (Essential Duties)
Perform hands-on qPCR and digital PCR assay development including primer/probe design
assay optimization and troubleshooting.
Execute experiments supporting feasibility verification and validation phases of molecular
diagnostic assay development.
Conduct nucleic acid extraction from human sample types (e.g. FFPE plasma) using standard
and automated workflows.
Develop and optimize assay conditions using DOE approaches and analyze data using statistical
software (e.g. R JMP).
Maintain compliant accurate laboratory documentation in an Electronic Laboratory Notebook
(ELN).
Prepare technical summaries reports and presentations for cross-functional project teams.
Follow all Roche safety quality and compliance practices including proper handling of biological
materials.
Author or update Standard Operating Procedures (SOPs) and study protocols as required.
Non-Essential Duties (CA Compliant Requirement)
These responsibilities support the role but are not essential functions:
Participation in cross-functional meetings beyond defined project deliverables.
Assisting with lab inventory supply management or general lab upkeep.
Required Qualifications
Education Requirements:
Bachelors degree in Molecular Biology Biochemistry Genetics or related field with 5 years of
relevant laboratory industry experience
Experience Requirements:
Demonstrated hands-on experience with qPCR assay development (required).
Proficiency with digital PCR (dPCR) platforms (e.g. Bio-Rad Qiagen).
Extensive knowledge of nucleic acid extraction quantification and quality assessment.
Experience interpreting complex datasets using statistical tools and DOE methods.
Strong documentation and communication skills in a regulated R&D environment.
Preferred Qualifications
Experience supporting oncology infectious disease or genomics-based assay development.
Experience working under IVD design control ISO 13485 or other regulated product
development frameworks.
Familiarity with automation systems LIMS ELN systems or high-throughput workflows.
Work Environment & Physical Requirements
The following reflect the physical and environmental expectations of this role:
Ability to stand or sit for extended periods while performing laboratory duties.
Ability to lift up to 20 pounds occasionally (e.g. reagent boxes equipment).
Manual dexterity required for pipetting and handling small laboratory components.
Work involves exposure to chemical reagents and human biological samples in a BSL-2
environment.
Personal Protective Equipment (PPE) such as lab coats gloves and safety glasses must be
worn as required.
Accommodations will be provided in accordance with the Americans with Disabilities Act (ADA) and
California FEHA.
Work Schedule
Standard schedule: Monday Friday normal business hours onsite.
Overtime is not anticipated and must be pre-approved if required.
Position does not include supervisory responsibilities.
Position Overview
The Scientist II will perform hands-on molecular laboratory work to support the design optimization and
development of qPCR and digital PCR (dPCR) assays for Roche Diagnostics advanced molecular
platforms. This role is classified as laboratory-based requiring routine work with chemical reagents and
human biological materials in a BSL-2 environment.
The individual in this role must be able to perform all essential functions listed below with or without
reasonable accommodation in accordance with ADA and California FEHA guidelines.
Key Responsibilities (Essential Duties)
Perform hands-on qPCR and digital PCR assay development including primer/probe design
assay optimization and troubleshooting.
Execute experiments supporting feasibility verification and validation phases of molecular
diagnostic assay development.
Conduct nucleic acid extraction from human sample types (e.g. FFPE plasma) using standard
and automated workflows.
Develop and optimize assay conditions using DOE approaches and analyze data using statistical
software (e.g. R JMP).
Maintain compliant accurate laboratory documentation in an Electronic Laboratory Notebook
(ELN).
Prepare technical summaries reports and presentations for cross-functional project teams.
Follow all Roche safety quality and compliance practices including proper handling of biological
materials.
Author or update Standard Operating Procedures (SOPs) and study protocols as required.
Non-Essential Duties (CA Compliant Requirement)
These responsibilities support the role but are not essential functions:
Participation in cross-functional meetings beyond defined project deliverables.
Assisting with lab inventory supply management or general lab upkeep.
Required Qualifications
Education Requirements:
Bachelors degree in Molecular Biology Biochemistry Genetics or related field with 5 years of
relevant laboratory industry experience
Experience Requirements:
Demonstrated hands-on experience with qPCR assay development (required).
Proficiency with digital PCR (dPCR) platforms (e.g. Bio-Rad Qiagen).
Extensive knowledge of nucleic acid extraction quantification and quality assessment.
Experience interpreting complex datasets using statistical tools and DOE methods.
Strong documentation and communication skills in a regulated R&D environment.
Preferred Qualifications
Experience supporting oncology infectious disease or genomics-based assay development.
Experience working under IVD design control ISO 13485 or other regulated product
development frameworks.
Familiarity with automation systems LIMS ELN systems or high-throughput workflows.
Work Environment & Physical Requirements
The following reflect the physical and environmental expectations of this role:
Ability to stand or sit for extended periods while performing laboratory duties.
Ability to lift up to 20 pounds occasionally (e.g. reagent boxes equipment).
Manual dexterity required for pipetting and handling small laboratory components.
Work involves exposure to chemical reagents and human biological samples in a BSL-2
environment.
Personal Protective Equipment (PPE) such as lab coats gloves and safety glasses must be
worn as required.
Accommodations will be provided in accordance with the Americans with Disabilities Act (ADA) and
California FEHA.
Work Schedule
Standard schedule: Monday Friday normal business hours onsite.
Overtime is not anticipated and must be pre-approved if required.
Position does not include supervisory responsibilities.
Key Skills
- Laboratory Experience
- Immunoassays
- Machine Learning
- Biochemistry
- Assays
- Research Experience
- Spectroscopy
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Data Analysis Skills
