2026 QTAS Intern Bispecific Antibody Stability for In Vivo Studies (PhD)

Envision spending your summer working with energetic colleagues and inspirational leaders all while gaining world-class experience in one of the most dynamic organizations in the pharmaceutical industry. This is a reality for AbbVie Interns.  

The intern will work in the Biologics Bioanalysis Characterization and Proteomics group at AbbVie focusing on evaluating the stability of bispecific antibodies using in vivo PK/TK study samples. This work compares two methods for quantification: the traditional multiplex assay which utilizes Multiple Reaction Monitoring (MRM) mass spectrometry to quantify variable regions on both heavy and light chains and a newer approach using a high-resolution mass spectrometer (HRMS) to quantify these antibodies at an intact level. The primary objective is to assess the consistency between these methods and determine whether the intact HRMS method could serve as a viable alternative for stability evaluation. This study aims to streamline the process potentially paving the way for broader methodological adoption and publication in internal and external journals. 

Key responsibilities include: 

• Familiarize with key lab instruments including Bravo AssayMAP Sciex Triple quad 7500 and Bruker maXis II qTOF. 

• Operate lab instruments by following historical protocols with used samples. 

• Complete online training sessions and develop an understanding of project planning. 

• Quantify variable regions using surrogate peptides for each chain with MRM on Sciex 7500 utilizing in vivo samples. 

• Quantify antibodies at intact level or subunits on Bruker qTOF with in vivo samples. 

• Analyze quantitative data using MultiQuant PMI Byos and Prism software. 

• Present the study findings at an internal poster/ oral presentation session. 

Qualifications :

MinimumQualifications 

• Currently enrolled in university pursuing a PhD in Chemistry Chemical Biology Pharmaceutical Sciences Biophysics or other related field 

• Must be enrolled in university for at least one semester following the internship  

• Good understanding of protein mass spectrometry 

• Hands-on experience of LC-MS analysis  

• Use Microsoft Office Excel Word and PowerPoint 

• Good written and verbal communication skills 

Preferred Qualifications 

• Expected graduation datebetween December 2026 June 2027 

• Exposure to protein bioanalysis with LC-MS  

• Hands-on experience of LC-MS analysis on Triple-quad and qTOF mass spectrometers 

• Hands-on experience of protein affinity purification 

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

Benefits and Amenities:

• Competitive pay

• Relocation support for eligible students

• Select wellness benefits and paid holiday / sick time 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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Work :

No

Employment Type :

Intern