proteogenomic studies of a wide range of cancers
detailed studies of cellular signaling networks related to protein phosphorylation ubiquitylation or acetylation
chemical proteomics technologies such as thermal profiling and cell surface proteomics
to unveil intracellular and cell-surface protein drug targets
developing biological understanding of response and resistance to therapy
Successful candidates will work in one or more of these areas together with an interdisciplinary team of clinicians biologists computational and proteomics scientists to deeply characterize and understand the proteomes of tumor-derived material cells and biofluids.
The Broad Institute is a world-leading non-profit research organization dedicated to realizing the promise of the post-genomic era for human benefit. Located in Cambridge MA with strong ties to MIT Harvard and world class Boston hospitals the Broad Institute brings together scientists of diverse backgrounds to solve critical problems in biology and medicine in an interdisciplinary manner.
The Broad Institute and the embedded Proteomics Group have an outstanding track-record in training the next generation of research scientists. We ( have a very strong track record in developing and applying proteomic technologies critical to address important questions in biology and medicine. We collaborate with top-level international researchers throughout the world and results of these studies and our technology developments are published in top-tier journals.
Qualifications Candidates must have:
an Ph.D. or MD PhD in areas such as analytical chemistry molecular biology biology biochemistry computational biology or preferably interdisciplinary sciences merging laboratory and bioinformatic skills
excellent scientific productivity evidenced by high-quality research publications in peer- reviewed journals
track record of conducting independent and creative research
analytical aptitude for devising innovative scientific or technical solutions
excellent verbal and written communication skills
Hands-on skills and knowledge in one or more of the following areas would be considered an advantage:
state-of-the-art mass spectrometry-based proteomics
expertise in statistical and/or computational analysis of large-scale proteomic or genomic data
analysis of cell signaling pathways/networks
cell biology/ biochemical methods to understand protein function
domain expertise in a disease area such as cancer metabolic or infectious disease
Required Experience:
IC
Broad Institute is a multidisciplinary community of researchers on a mission to improve human health.