Bioprocess Development Senior Bioprocess EngineerScientist

Emeryville, CA - USA

Monthly Salary: Not Disclosed

Posted on: 10-11-2025

Vacancies: 1 Vacancy

Job Summary

Prolific Machinesis ushering in a new era of biotechnology with light. Our mission is to make next-generation therapies broadly available to patients. Our first-of-its-kind Photomolecular Platform uses light to precisely guide how cells produce complex biologics enabling higher titers improved quality and faster development timelines. By helping partners overcome todays manufacturing bottlenecks were accelerating the delivery of life-changing medicines. Prolific is supported by leading investors including Bill Gatess Breakthrough Energy Ventures Mayfield and SOSV.

Help us create a brighter tomorrow with biology. Were looking for mission-driven talented and kind people to join our team.

Were looking for a dedicated bioprocess engineer or scientist with experience in CHO cell cultures to develop and optimize our antibody production processes. This role will lead the development of high titer processes for Prolifics mammalian cell line as well as potential process and technology solutions to benefit our core technology. They will also lead the process development of specific mammalian cell lines to design optimize and eventually scale-up the process to production scales. The successful candidate will collaborate with multiple stakeholders across the company to deliver our processes and technology for the benefit of the strategic portfolio. This position will report into the Senior Director of Technical Operations.

Responsibilities

Lead development of high titer processes and evaluate innovative technologies and solutions.
Design and development of CHO cell culture process starting from clonal handoff to production scale bioreactors.
Design and execute experiments at benchtop scale to determine optimal process parameters as well as process optimization to establish robust and scalable cell culture processes for various mammalian cell types.
Serve as an organizational subject matter expert in CHO cell culture processes and bioreactor scale-up.
Ensure technologies are in place to improve process efficiency and productivity. Work with the BPD team to expand capabilities and productivity.
Collaborate with cell line development bioprocess engineering and product development teams for the cross-functional coordination to make key decisions on tech transfers and technical support.
Communicate with third-parties suppliers and partners for ingredients equipment and novel approaches to process development and bioreactor technology.

About You

Excellent verbal and written communication skills with clarity in communication around the tradeoffs in scope quality time and (human) resources.
You come with creative cost-effective solutions to accelerate timelines. You know when to be flexible and when to be assertive and communicate what you know is right.
You are an effective integrator - you are a quick learner and effective facilitator and can integrate knowledge data and experience from others to make efficient progress.
You are a thoughtful coworker who cares deeply about the companys mission and culture.
You thrive in a dynamic environment and can take on the plurality of challenges that are inherent to startups.
You foster a team environment and you actively seek impactful feedback from your colleagues.

Qualifications

Advanced degree (MS or PhD preferred BS acceptable with equivalent experience) with 5 years of experience in technical development in a biopharmaceutical or similar industry.
Extensive experience in CHO cell culture development with strong technical understanding of cell culture processes scale-up principles and optimization techniques.
Experience with process development from both an early stage and late stage perspective. Experience with benchtop scales (250ml - 10L) is a must experience with larger scales (50L - 1KL) is a plus.
Experience with single use bioreactors is a plus.
Strong understanding/experience in experimental design including design of experiment (DOE) and subsequent data analysis through SIMCA JMP or Python.
Excellent verbal and written communication skills with clarity in communication around the tradeoffs in scope quality time and (human) resources.
Understanding of CHO cell biology cell line engineering and development.

$135000 - $175000 a year

Starting salary will be dependent upon specific experience knowledge and skillset along with exact role type and level hired for.

Benefits:Generous equity package in an early stage company retirement plan with company contribution flexible PTO with healthy time off minimums company-covered medical dental and vision insurance life and disability insurance career coaching mental health support free team lunches everyday great snacks and companywide social events!

Diversity:We value diverse people perspectives and knowledge. To this end we aim to foster a sense of belonging that enables everyone to bring their whole authentic self to work everyday. We are committed to growing a diverse and inclusive team that encompasses all types of people. We believe this can only be achieved by acknowledging the ancestral historic and current systemic and communal inequities.

Required Experience:

Senior IC