Research CO-OP

Site: The Brigham and Womens Hospital Inc.

Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

The Channing Division of Network Medicine at Brigham and Womens Hospital is looking for exceptional
Northeastern University trainees to join the Systems Genetics and Genomics group advancing research on
chronic respiratory diseases with a focus on identifying multi-omics biomarkers for chronic obstructive
pulmonary disease (COPD).
Brigham and Womens Hospital a major teaching hospital of Harvard Medical School is an international leader
in healthcare dedicated to improving global well-being through excellence in clinical care and groundbreaking
research. Serving patients from over 120 countries the hospital has a legacy of innovation and impact.
This internship is within the Channing Division of Network Medicine a research division in the Department of
Medicine at Brigham and Womens Hospital and Harvard Medical School. We employ an integrated networkbased
systems biology-driven approach to uncover the origins of complex diseases with the goal of redefining
them by revealing their fundamental pathobiological mechanisms. This work aims to enable novel treatment and
preventive strategies grounded in revolutionary systems-driven disease classifications. The Division includes over
50 distinguished primary faculty members with expertise spanning epidemiology statistics bioinformatics
genetics epigenetics transcriptomics metabolomics metagenomics and network-based analyses of complex
human diseases.
The principal investigators research focuses on identifying novel COPD biomarkers applying machine learning
to define its clinical and molecular basis and developing clinical prediction tools using multi-omics data. COPD
affects up to 24 million individuals in the United States contributing substantially to morbidity and mortality yet
no disease-modifying therapies currently exist. Our group has led some of the largest genetic and multi-omics
studies in obstructive lung diseases uncovering new molecular associations and pathways. The intern will work
with Dr. Castaldi and Dr. El Boueiz to identify novel multi-omics biomarkers and molecular subtypes of
emphysema using a systems biology approach. This project will leverage two large well-phenotyped NIH-funded
studies (COPDGene and Lung Tissue Research Consortium (LTRC)) along with the teams extensive expertise
in advanced imaging multi-omics data analysis and machine learning.

Responsibilities:
Under the direction of the PIs and research staff the applicant is expected to independently carry out daily
research activities.
Work with our interdisciplinary team consisting of epidemiologists biostatisticians computational
biologists translational scientists and clinicians.
Review the literature and become familiar with the epidemiologic and multi-omics studies that are relevant
to the research project.
Program and analyze data using R / Bioconductor and Linux.
Write abstracts posters and manuscripts.
Qualifications:
Prior experience in programming languages and bioinformatics tools commonly used in computational
biology. Most of our research projects use the R or Python. While some on the job learning is expected
interns who do not have some degree of exposure to programming will not be well-positioned for this
position.
Excellent written and oral communication skills to convey research findings collaborate with team
members and present at conferences.
Willingness and ability to adapt to new technologies tools and research directions as the field evolves.
Act with ethics and integrity ensuring that all aspects of work meet or exceed professional standards.
Build strong positive working relationships with others (manager peers other coworkers)
Strong project management skills to plan execute and complete research projects on time with the ability
to maintain a detailed and well-organized record of the research performed and the results obtained.
Demonstrate dependability (e.g. report consistently and on time for work appointments and meetings)
Ability to resolve technical problems and analytical skills if necessary
Accept feedback and use it to strengthen future performance
Training goals:
Acquire advanced skills for analyzing complex biological data including high-throughput data.
Develop advanced proficiency in programming and bioinformatics.
Develop strong critical thinking and problem-solving skills to address complex biological questions.
Publish research findings in reputable journals and present work at conferences.
Meet with the PIs at least twice weekly to discuss research findings solicit feedback evaluate progress
and provide appropriate support and mentoring.
Receive guidance on career planning and job search strategies

Hybrid

181 Longwood Avenue

0

Per Diem

Day (United States of America)

Pay Range

$17.36 - $23.80/Hourly

Grade

2

At Mass General Brigham we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive and any offer extended will take into account your skills relevant experience if applicable education certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however it does not encompass all elements contributing to your total compensation addition to competitive base pay we offer comprehensive benefits career advancement opportunities differentials premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.

The Brigham and Womens Hospital Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religious creed national origin sex age gender identity disability sexual orientation military service genetic information and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973 the Vietnam Veterans Readjustment Act of 1974 and Title I of the Americans with Disabilities Act of 1990 applicants who require accommodation in the job application process may contact Human Resources at .

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