Principal Staff Scientist

Job Summary:

This role offers an exceptional opportunity to conduct high-impact research focused on uncovering the underlying causes of diabetes with the goal of advancing treatment and prevention strategies. You will collaborate closely with leading scientists at the Barbara Davis Diabetes Center and the Department of Biochemistry and Molecular Biology contributing to groundbreaking discoveries in diabetes research. The projects will explore pancreatic beta cell biology to uncover how beta cells contribute to autoimmune processes in type 1 diabetes and to functional impairment in type 2 particular one line of investigation will examine how mRNA translation regulation shapes the production of neoantigens that drive autoimmune activation in type 1 this role you will design develop and perform experiments using cellular systems islets animal models and human samples to explore key molecular mechanismsincluding mRNA translation protein expression beta-cell function and immune cell infiltration.

Key Responsibilities:

Maintain islet and cell cultures

Maintain necessary animal cohorts

Design and perform experiments primarily in molecular biology

Organize data and present to the group

Contribute to manuscript preparation for publication in peer-reviewed journals

Work Location:

Onsite this role is expected to work onsite and is located in Aurora Colorado.

Why Join Us:

The Barbara Davis Center (BDC) is a unique entity located on the University of Colorado Anschutz Medical Campus devoted to treating patients with Type 1 diabetes (T1D) and performing research to prevent and cure T1D. The BDC Research Division consists of 12 independent research labs focused on all aspects of T1D research including immunology islet biology and stem cell biology. The Sussel lab uses sophisticated molecular techniques and mouse and human stem cell models to characterize the role of islet dysfunction in contributing to T1D.

Why work for the University

We haveAMAZINGbenefits and offerexceptional amounts of holiday vacation and sick leave! The University of Colorado offers an excellent benefits package including:

• Medical: Multiple plan options
• Dental: Multiple plan options
• Additional Insurance: Disability Life Vision
• Retirement 401(a) Plan: Employer contributes 10% of your gross pay
• Paid Time Off: Accruals over the year
• Vacation Days: 22/year (maximum accrual 352 hours)
• Sick Days: 15/year (unlimited maximum accrual)
• Holiday Days: 10/year
• Tuition Benefit: Employees have access to this benefit on all CU campuses
• ECO Pass: Reduced rate RTD Bus and light rail service

There are many additional perks & programs with the CU Advantage.

Qualifications:

Minimum Qualifications:

Bachelors degree in biology molecular biology chemistry genetics or related field

Three (3) years professional level research experience

Preferred Qualifications:

Masters degree in biology molecular biology chemistry genetics or related field

Four (4) years of experience in an experimental or wet laboratory mammalian cell culture and animal physiology

Knowledge Skills and Abilities:

Expert knowledge of laboratory techniques including safety procedures and techniques

Expert ability to analyze and solve complex problems

Ability to communicate effectively both in writing and orally

Ability to establish and maintain effective working relationships with employees at all levels throughout the institution

Outstanding customer service skills

Knowledge of basic human anatomy physiology medical terminology

Ability to interpret and master complex research protocol information

Expert level knowledge of mammalian cell culture genome editing next generation sequencing RNA/DNA quantification using ddPCR qRT-PCR protein expression and detection in vivo delivery of genome editing agents

How to Apply:

For full consideration please submit the following document(s):

1. A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position.

2. Curriculum vitae / Resume

3. Three to five professional references including name address phone number (mobile number if appropriate) and email address

Questions should be directed to: BDC Human Resources

Screening of Applications Begins:

Screening begins on 10/21/25

Anticipated Pay Range:

The starting salary range (or hiring range) for this position has been established as HIRING RANGE: $62606-$79635.

The above salary range (or hiring range) represents the Universitys good faith and reasonable estimate of the range of possible compensation at the time of posting. This position may be eligible for overtime compensation depending on the level.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave health plans and retirement contributions that add to your bottom line.

Total Compensation Calculator

Equal Employment Opportunity Statement:

CU is an Equal Opportunity Employer and complies with all applicable federal state and local laws governing nondiscrimination in employment. We are committed to creating a workplace where all individuals are treated with respect and dignity and we encourage individuals from all backgrounds to apply including protected veterans and individuals with disabilities.

ADA Statement:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act please contact the Human Resources ADA Coordinator at

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty staff students and visitors. To assist in achieving that goal we conduct background investigations for all prospective employees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19 virus and othervaccine preventable diseases. If you work visit or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work visit or volunteer addition if you work in certain research areas or perform certain safety sensitive job duties you must enroll in theoccupational health medical surveillance program.