Vice President, Disease Area Franchise Head, Clinical Development

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As Franchise Head reporting to the VP Head of Clinical Development you will lead and oversee multiple clinical science teams responsible for developing global clinical development plans and ensuring effective and efficient execution for multiple molecules within the assigned disease-area indication. You will guide strategy priorities and interpretation of clinical study results. You will interact at high levels internally (e.g. the Development Leadership Team DRG chairs) and externally (health authorities key opinion leaders) serving as both a consultant/advisor to RevMed committees and as a public face for the therapeutic area. You will provide guidance to Development Project Team Leads for the development programs under your leadership and shape disease-areas late-stage portfolio strategy ensuring alignment between R&D regulatory and commercial goals.

Key Responsibilities:

• Lead and own theglobal clinical development strategy and roadmapfor the disease area (lung / colon / pancreas cancer) spanning preclinical through late-phase development regulatory interactions and support for eventual commercialization.

• Oversee execution of multiple molecule programs within the disease area: ensure high quality protocol design site selection patient recruitment data integrity regulatory compliance and risk/benefit evaluation.

• Serve asclinical & scientific thought leaderin the disease area: monitor external science competitive intelligence emerging modalities biomarkers; integrate translational science into clinical programs.

• Act as a primary interface with regulatory authorities KOLs external experts/ advisory boards (domestic & international) for clinical strategy plan negotiation and feedback.

• Partner closely with cross-functional organizations including Research Regulatory Affairs Translational Medicine Medical Affairs Commercial Operations and Finance to ensure alignment of scientific regulatory and commercial objectives.

• Mentor develop recruit and retain talent in your teams; provide leadership to direct reports and non-direct report team members. Ensure training career development and performance management.

• Manages direct reports and is accountable for hiring training developing and retaining talent on his/her staff. Ensures consistent compliance with all governing employment laws regulations and RevMed HR policies and procedures. Demonstrates strong people leadership through delegating effectively empowering teams and ensuring accountability for high-quality outcomes. Prior people-management experience is required with a proven ability to motivate coach and lead both direct and indirect team members toward successful program delivery.

• Establish and maintain processes tools systems needed to scale clinical development in the disease area: improve efficiency quality regulatory compliance.

• Oversee budgets resources timelines and milestone achievement for disease-area programs. Prioritize between projects; make trade-off decisions as needed.

• Serve on and provide input to internal RevMed governance / committee structures (e.g. DevLT DRG protocol review committees).

• Represent RevMed externally: present disease area and molecule development plans clinical data and strategy to regulatory agencies at conferences in publications.

• Ensure adherence to GCP ICH FDA/EMA (and other relevant health authority) guidelines quality assurance safety monitoring benefit-risk assessment.

• Define and drive the disease-area clinical vision; integrating translational science regulatory pathways and commercial readiness.

• Lead enterprise portfolio prioritization and investment trade-off decisions through collaboration with R&D Commercial and Finance.

Required Skills Experience & Education:

• MD PhD or equivalent advanced biomedical degree with15 yearsexperience in pharmaceutical / biotech industry (including clinical development in oncology / solid tumors); academic faculty experience outside of industry considered pending transferability of skills and responsibilities.

• Extensive oncology clinical development experience with deep expertise in solid tumors and a demonstrated ability to rapidly build and apply disease-area knowledge (e.g. lung colon pancreas) to guide program strategy and execution.

• Experience authoring and leading clinical development strategies including label-enabling outcomes regulatory submissions (e.g. NDA/BLA/MAA) in global settings.

• Strong scientific credibility: publications in peer-reviewed journals external recognition (KOLs conferences).

• Proven ability to lead large cross-functional teams including both direct and indirect reports; proven ability to mentor motivate retain high caliber clinical scientists.

• Demonstrated ability to manage clinical budgets timelines resources; strong decision-making in trade-off situations balancing safety efficacy speed cost.

• Excellent communication presentation interpersonal skills; ability to influence and collaborate with senior management external stakeholders regulatory agencies.

• Experience influencing corporate strategy and external industry direction including partnerships senior level interactions or health authority representation.

• Organizational scaling experience including leading through growth change and commercialization.

Preferred Skills:

• Experience with biomarker-driven trial design precision medicine translational science relevant to cancer.

• Prior experience building or refining processes systems tools for scaling clinical development in a disease area.

• Experience with commercialization lifecycle post-approval studies / life-cycle management.

• Experience interacting with health authorities globally across multiple regions.

• Experience in M&A / in-licensing or partnering for external assets relevant to disease-area.

• Successful experience presenting external scientific strategy communicating to external advisory boards investigator meetings.

• Oversee multiple Clinical Science teams and Project Team Leads for the disease area. Interacts with cross-functional leads in Translational Regulatory and Medical Affairs (amongst others) as matrix.

• Frequent interaction with DevLT (Development Leadership Team) DRG (Development Research Group) Chairs Regulatory Affairs Finance Commercial Research & Translational Medicine. #LI-Hybrid #LI-GL1