Senior Specialist, Quantitative Pharmacology and Pharmacometrics Infectious Disease and Vaccines

Job Description

Senior Specialists in the Infectious Disease and Vaccines group in the department of Quantitative Pharmacology and Pharmacometrics (QP2) apply quantitative approaches to enable drug-development decision-making from drug discovery through approval.

Senior Specialists will work in collaborative teams and with more experienced scientists across disciplines and are expected to have or develop expertise in one or more areas necessary to perform the primary responsibilities of the role including:

• Applying quantitative approaches to develop and implement translational clinical pharmacokinetics and pharmacodynamics of new drug and vaccine candidates

• Developing and executing pharmacokinetics and pharmacodynamics modelling approaches such as noncompartmental analysis population pharmacokinetic exposure-response quantitative system pharmacology viral dynamics model-based meta-analysis and other model-based analyses

• Perform clinical trial simulations to inform dose selection and go/no-go decisions

• Serve as a QP2 representative while being mentored by QP2 senior staff on drug and vaccine development teams to manage functional deliverables for assigned programs

On the job you will begin to develop a comprehensive understanding of global regulatory expectations of drug and vaccine development including clinical trial design clinical pharmacology biomarker plans and model-based drug development approaches. You will also develop leadership skills in areas such as mentoring managing a program project or initiative. Collaboration within the group and with other functional areas as well as with external vendors and partners to create an aligned quantitative framework to impact decisions of drug development teams is also crucial.

The ideal candidate is collaborative and eager to learn. Excellent communication skills both written and verbal are required including the ability to clearly present scientific data in cross functional group settings.

QP2 offers a unique opportunity to accelerate your professional career as a quantitative drug developer taking advantage of our end-to-end pipeline support in one of the worlds most research-intensive biopharmaceutical companies.

Minimum required education:

• A Ph.D. or equivalent degree - OR- a PharmD or equivalent degree with at least two years of experience - OR- a MS or equivalent degree with at least four years of experience where experience means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia

• An educational background in PK/PD pharmaceutical sciences pharmacometrics mathematics statistics/ biostatistics computational biology/chemistry chemical/biomedical engineering or a related field.

Required experience and skills:

• Proficiency in R NONMEM Matlab Python or a similar programming language

• Proficiency in written and verbal communication

Preferred experience and skills:

• Knowledge of infectious diseases

• Experience performing population PK and/or PK/PD analyses

• Experience with standard pharmacometrics software (e.g. NONMEM Monolix Phoenix.)

• Skills in experimental design mathematical problem solving critical data analysis/interpretation and statistics

• Scientific understanding of ADME and biopharmaceutic properties of biologics small molecules or non-traditional therapeutics

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Effective September 5 2023 employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week Monday - Thursday although the specific days may vary by site or organization with Friday designated as a remote-working day unless business critical tasks require an on-site Hybrid work model does not apply to and daily in-person attendance is required for field-based positions; facility-based manufacturing-based or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.

The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

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