Associate Staff Scientist

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Closing Date:

11/28/2025

Type of Position:

Researchers

Job Type:

RegularNo

Institution Name:

University of Arkansas for Medical Sciences

The University of Arkansas for Medical Sciences (UAMS) has a unique combination of education research and clinical programs that encourages and supports teamwork and diversity. We champion being a collaborative health care organization focused on improving patient care and the lives of Arkansans.

UAMS offers amazing benefits and perks (available for benefits eligible positions only):

• Health: Medical Dental and Vision plans available for qualifying staff and family
• Holiday Vacation and Sick Leave
• Education discount for staff and dependents (undergraduate only)
• Retirement: Up to 10% matched contribution from UAMS
• Basic Life Insurance up to $50000
• Career Training and Educational Opportunities
• Merchant Discounts
• Concierge prescription delivery on the main campus when using UAMS pharmacy

Below you will find the details for the position including any supplementary documentation and questions you should review before applying for the opening. To apply for the position please click theApply link/button.

The University of Arkansas is an equal opportunity institution. The University does not discriminate in its education programs or activities (including in admission and employment) on the basis of any category or status protected by law including age race color national origin disability religion protected veteran status military service genetic information sex sexual orientation or pregnancy. Questions or concerns about the application of Title IX which prohibits discrimination on the basis of sex may be sent to the Universitys Title IX Coordinator and to the U.S. Department of Education Office for Civil Rights.

Persons must have proof of legal authority to work in the United States on the first day of employment.

All application information is subject to public disclosure under the Arkansas Freedom of Information Act.

For general application assistance or if you have questions about a job posting please contact Human Resources at .

Department:

COM Biochemistry - Enemark Lab

Departments Website:

Summary of Job Duties:

A Research Staff Scientist position is available in the newly established Structural Biology Core at the University of Arkansas for Medical Sciences (UAMS). This position will apply specialized expertise in cryo-electron microscopy (cryo-EM) and X-ray crystallography to advance the structural biology research capabilities of UAMS and the Arkansas INBRE network.

The Winthrop P. Rockefeller Cancer Institute (WPRCI) has made significant investments to strengthen structural biology and integrate it into its cancer research programs including the purchase of a Glacios cryo-EM scheduled for installation in 2026.

The successful candidate will perform independent structure determination by cryo-EM and X-ray crystallography assist in sample preparation and data collection and train users on the best practices for instrument operation and experimental design. This is an exciting opportunity to contribute to high-impact multidisciplinary research within a collaborative team-oriented environment that spans UAMS and regional partners.

Qualifications:

• Ph.D. in Bioscience Biochemistry Structural Biology or a related PLUS five (5) years of laboratory experience in structural biology including both X-ray crystallography and cryo-EM

• Demonstrated expertise in gene-to-structure determination including protein expression purification crystallization and structure analysis

• Proven record of successful cryo-EM structure determination supported by peer-reviewed publications or scientific presentations

• Experience with bacterial protein expression and purification

Knowledge Skills and Abilities:

• Proficiency with structural biology software such as RELION CryoSPARC Phenix CCP4 and Coot

• Strong understanding of protein biochemistry molecular biology and macromolecular structure-function relationships

• Experience with Linux-based computational environments for data analysis and modeling

• Ability to troubleshoot complex experimental and computational workflows

• Excellent organizational communication and documentation skills

• Demonstrated ability to work both independently and collaboratively in a multidisciplinary research setting

• Commitment to maintaining safety data integrity and scientific rigor in all laboratory activities

Preferred Qualifications:

• Experience expressing and purifying proteins using mammalian yeast or insect cell systems

• Experience assisting and mentoring scientists in structure determination by cryo-EM and/or X-ray crystallography

• Strong collaborative and problem-solving skills

This position is a Designated Research Position and involves scientific investigation or development that involves technologies designs or technical data considered sensitive enough to potentially impact national security and therefore requires strict controls on export or transfer to foreign entities. The Arkansas Research & Education Protection Act of 2025 requires the University to obtain additional information about your background for this Research Position.

Additional Information:

Responsibilities:

• Conduct structural biology research using cryo-electron microscopy (cryo-EM) and X-ray crystallography.

• Prepare and freeze grids evaluate samples by negative stain and cryo-EM and collect high-resolution cryo-EM data.

• Perform particle selection classification and structure refinement to determine and finalize coordinate structures.

• Conduct crystallization screening crystal optimization X-ray diffraction data collection structure solution and refinement.

• Prepare and purify samples for analysis by cryo-EM and X-ray crystallography.

• Train students postdoctoral fellows and scientists in structural biology techniques.

• Supervise laboratory staff and ensure compliance with all University State and Federal safety regulations.

• Maintain and operate laboratory equipment including FEI Vitrobot Leica GP2 Mosquito crystallization robot and Formulatrix plate hotel.

• Manage inventory order supplies and track equipment service and maintenance schedules.

• Supervise and support personnel in developing new laboratory protocols.

• Collaborate with faculty students and postdoctoral fellows to advance research projects.

• Work independently while maintaining consistent communication with the Principal Investigator.

• Perform additional duties as assigned.

Salary Information:

Commensurate with education and experience.

Required Documents to Apply:

List of three Professional References (name email business title) Resume

Special Instructions to Applicants:

Please contact for any recruiting relatedquestions.

All application materials must be uploaded to the University of Arkansas System Career Site

Please do not send to listed recruitment contact.

Pre-employment Screening Requirements:

Criminal Background Check

This position is subject to pre-employment screening (criminal background drug testing and/or education verification). A criminal conviction or arrest pending adjudication alone shall not disqualify an applicant except as provided by law. Any criminal history will be evaluated in relationship to job responsibilities and business necessity. The information obtained in these reports will be used in a confidential non-discriminatory manner consistent with state and federal law.

Constant Physical Activity:

N/A

Frequent Physical Activity:

Feeling Hearing Sitting Standing Talking Walking

Occasional Physical Activity:

Crawling Crouching Kneeling Lifting Pulling Pushing Reaching Stooping

Benefits Eligible:

Yes