Head of Computational Chemistry

Villigen - Switzerland

Monthly Salary: Not Disclosed

Posted on: 30+ days ago

Vacancies: 1 Vacancy

Job Summary

Principal Scientist, Head of Computational Chemistry, Argau Canton , Switzerland, Permanent job

The company

The company is a rapidly growing biotech company focusing on solving structures of membrane protein drug targets (e.g. GPCRs, ion-channels and transporters) for the discovery and optimization of next-generation medicines. Based on a unique platform for membrane protein expression, purification and engineering, and preferential access to synchrotron and free electron laser beamlines for X-ray analysis and cryo-EM facilities, they characterize the interaction of small molecules and biotherapeutics with drug targets in time to impact the discovery of novel therapeutics.

Key tasks and responsibilities

Utilize modern molecular modelling methods to support different stages of R&D programs.
Collaborate effectively with other functions to advance research discovery projects expeditiously from early target assessment to hit-to-lead and lead optimization.
Design, lead and drive computational studies on projects throughout the several discovery phases and ensure on agreed deliverables.
Set the vision and strategy for computational chemistry.
Manage data warehousing for lead discovery projects using CDD Vault to facilitate secure and efficient data management and collaboration.
Collaborate with external partners on joint drug discovery projects.
Present plans and results internally, including at board level, and externally at conferences.
Keep up to date with the latest scientific advances and trends in drug discovery to deliver the next-generation therapies.

Your qualification

MSc/PhD in a relevant scientific discipline (Pharmaceutical Sciences, Chemistry, Computational Chemistry) with a solid foundation in molecular modelling built in a pharma/biotech/CRO setting.
Expert knowledge in CADD software packages and modern molecular modelling techniques.
Sound knowledge in cutting-edge cheminformatic tools, AI/ML-enabled technologies, and in silico drug design, including both structure- and ligand-based methodologies.
Passion for drug discovery with a deep understanding of membrane protein drug targets (e.g. GPCRs, ion-channels and transporters).
Mastery of all the theoretical and practical principles of medicinal chemistry and drug design.
Broad knowledge of biophysical, biochemical, and cell-based assays used in the early stages of the drug discovery process.
In depth understanding of multi-parameter optimization and ability to integrate disease biology, ADME/DMPK and toxicology data to solve complex drug discovery problems.
Excellent leadership, management, organizational and team-working skills, and a talent to deliver project milestones within the expected time frame.
Demonstrated track record of scientific publications.

Benefits

You will be working for an innovative company aiming to discover new generation medic
You will be working with state-of-art technologies
You will be working in a supportive and dynamic team
Share options bonus

If you are interested, please send a CV.

It is essential that applicants hold entitlement to work in Switzerland. Please quote job reference 156433 in all correspondence.

Principal Scientist, Head of Computational Chemistry, Argau Canton , Switzerland, Permanent job The company The company is a rapidly growing biotech company focusing on solving structures of membrane protein drug targets (e.g. GPCRs, ion-channels and transporters) for the discovery and optimization ...

Utilize modern molecular modelling methods to support different stages of R&D programs.
Collaborate effectively with other functions to advance research discovery projects expeditiously from early target assessment to hit-to-lead and lead optimization.
Design, lead and drive computational studies on projects throughout the several discovery phases and ensure on agreed deliverables.
Set the vision and strategy for computational chemistry.
Manage data warehousing for lead discovery projects using CDD Vault to facilitate secure and efficient data management and collaboration.
Collaborate with external partners on joint drug discovery projects.
Present plans and results internally, including at board level, and externally at conferences.
Keep up to date with the latest scientific advances and trends in drug discovery to deliver the next-generation therapies.

Your qualification

MSc/PhD in a relevant scientific discipline (Pharmaceutical Sciences, Chemistry, Computational Chemistry) with a solid foundation in molecular modelling built in a pharma/biotech/CRO setting.
Expert knowledge in CADD software packages and modern molecular modelling techniques.
Sound knowledge in cutting-edge cheminformatic tools, AI/ML-enabled technologies, and in silico drug design, including both structure- and ligand-based methodologies.
Passion for drug discovery with a deep understanding of membrane protein drug targets (e.g. GPCRs, ion-channels and transporters).
Mastery of all the theoretical and practical principles of medicinal chemistry and drug design.
Broad knowledge of biophysical, biochemical, and cell-based assays used in the early stages of the drug discovery process.
In depth understanding of multi-parameter optimization and ability to integrate disease biology, ADME/DMPK and toxicology data to solve complex drug discovery problems.
Excellent leadership, management, organizational and team-working skills, and a talent to deliver project milestones within the expected time frame.
Demonstrated track record of scientific publications.

Benefits

You will be working for an innovative company aiming to discover new generation medic
You will be working with state-of-art technologies
You will be working in a supportive and dynamic team
Share options bonus

If you are interested, please send a CV.

It is essential that applicants hold entitlement to work in Switzerland. Please quote job reference 156433 in all correspondence.