Principal scientist, Oncology (3D In Vitro Modelling – Micofluidics)

427676 Principal scientist Oncology (3D In Vitro Modelling Micofluidics)

We are looking for a highly motivated scientist with experience in microfluidics fluorescence and label-free microscopy applied to complex in vitro systems (organoid immune cells fibroblasts and tissues) and extensive oncology cellular biology to join the Oncology Translational Research team within GSK Oncology.

The Oncology Translational Research team will partner with other Oncology Therapy Area team members to increase clinical translatability and to contribute to preclinical development programs within GSK Oncology TA.

The successful candidate will work in a small team involved in the establishment of a new organoid-on-a-chip platform combined with a microfluidic system and single cell detection. This research platform will be used to develop and implement cutting-edge cellular genomic and molecular techniques with a multimodality analytic approach generating data that will inform machine learning models to improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities.

Please note that this position will need to be predominantly lab-based with some ad hoc flexibility to work from home.

We create a place where people can grow be their best be safe and feel welcome valued and included. We offer a competitive salary an annual bonus based on company performance healthcare and wellbeing programmes pension plan membership and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK GSK

In this role you will

• Establish organoid-on-a-chip platforms that incorporate multiple cell types (immune cells/ fibroblasts/tumour cells/endothelial cells)
• Develop a microfluidic system for modelling immune cell action and drug penetration into 3D organoid models
• Develop protocols for whole-organoid imaging as well as single-cell analysis
• Data collection and reporting to the laboratory head
• Execute and deliver the project

Why you

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• MSc in Cell Biology/Oncology/Biotechnology/Bioengineering/Chemical Biology
• Experience in 3D organ-on-a-chip systems and single cell analysis on patient-derived organoids
• Experience in microfluidic and chip devices including device fabrication
• Ability to communicate with team members from different backgrounds by training/discipline as well as senior members of the GSK stakeholders/research partner units
• Ability to deliver high quality consistent results in a timely fashion with a positive can-do and result-oriented attitude

Preferred Qualifications & Skills:

Please note the following skills are not necessary just preferred if you do not have them please still apply:

• PhD in Cell Biology/Oncology or Bioengineering/Chemical Biology
• Laboratory automation experience
• Experience with cancer immunology
• Experience in wide-field imaging and/or confocal microscopy
• Any additional experience in advanced light microscopy and quantitative imaging techniques

Closing Date for Applications 29th of September 2025 (COB)

Please take a copy of the Job Description as this will not be available post closure of the advert.

When applying for this role please use the cover letter of the online application or your CV to describe how you meet the competencies for this role as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK we have bold ambitions for patients aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines combining our understanding of the immune system with cutting-edge technology to transform peoples fosters a culture ambitious for patients accountable for impact and committed to doing the right thing making sure that we focus our efforts on accelerating significant assets that meet patients needs and have the highest probability of success. Were uniting science technology and talent to get ahead of disease together.

Find out more:

Our approach to R&D.

Why GSK
Uniting science technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade as a successful growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.

People and patients around the world count on the medicines and vaccines we make so were committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients accountable for impact and doing the right thing is the foundation for how together we deliver for patients shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race color religion sex (including pregnancy gender identity and sexual orientation) parental status national origin age disability genetic information (including family medical history) military service or any basis prohibited under federal state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you we encourage you to explore with our hiring team what the opportunities are.

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