Research Associate, Preclinical
Research Associate, Preclinical
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Job Description
Acuitas Therapeutics is a private biotechnology company located at 6190 Agronomy Rd #402 VancouverBritish Columbia Canada. We are the premier global provider of LNP delivery systems for nucleic acid therapeutics. Acuitas is partnered with multiple international biotechnology and pharmaceutical partners who are focused on bringing new vaccines and drugs into clinical development and to the marketplace.
At Acuitas we believe in combining excellent science with an enviable work culture. The advanced LNP technologies we provide for our partners are made possible by our employees who apply their passion curiosity and knowledge every step of the way. At Acuitas you will have the opportunity to work as part of a close-knit team of exceptional scientists who support the production of revolutionary technology that impacts the health and wellness of society. By living our values including honesty integrity innovation and openness we have fostered a supportive work environment where our employees feel empowered challenged recognized and rewarded. If you would like to work for a company that is at the top of the field Acuitas is the company for you!
All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity national origin disability or any other status protected by applicable law.
Job Title: Research Associate Preclinical
YOU: A committed professional with experience in preclinical research looking to develop further in an innovative fast paced biotech environment.
US: Leading innovators in the lipid nanoparticle (LNP) field looking for a talented individual to join our collaborative passionate and diverse results focused team.
ROLE SUMMARY: Acuitas Therapeutics is seeking a permanent full-time Research Associate with a strong background in immunology and immunological methods to work in the Preclinical team reporting to the Senior Research Scientist Preclinical. The role holder will be responsible for executing and supporting studies assessing the pharmacology immunology mechanism of action distribution and safety profile of our LNP executing analyses and data interpretation and presenting results to the team and company.
Working with the Preclinical team the responsibilities would include:
- Executing and supporting studies to evaluate LNP activity distribution mechanisms of action immune profiles and safety.
- Mastering established methods and developing new methods to support preclinical objectives including ELISA MSD luciferase assays qPCR SDS-PAGE DNA/RNA isolation and protein quantification.
- Cell culture and cell-based assays (including ELIspot) cell isolation and processing tissues and fluids for downstream analysis.
- Hands-on experience in multi-colour flow cytometry intracellular cytokine staining and gating strategies.
- General laboratory support including preparation of reagents and solutions laboratory organization maintaining sample and reagent inventory and shipping of materials.
- Up to date Biosafety/Biosecurity (Containment Level 2) and WHMIS certification will be required.
- Maintain familiarity with relevant scientific knowledge and advancements in LNP technology.
- May be required to train more junior staff and co-op students.
QUALIFICATIONS AND SKILLS:
- BSc with 2-10 years experience or an MSc with up to 7 years experience; some industry experience preferred.
- Hands-on experience conducting experiments with LNP in vitro and ex vivo; knowledge of LNP formulation processes LNP characteristics in vivo biodistribution pharmacodynamics and pharmacokinetics
- Strong background in innate and adaptive immunology. Knowledge specific to LNP preferred.
- Strong understanding of cell biology and human physiology with a focus on liver structure and function as well as other fenestrated organs.
- Background in vaccine development and experience conducting/analyzing associated assays (ELISA EliSpot HAI)
- Hands-on experience in tissue isolation single cell preparation cell culture cell-based assays and cell differentiation.
- Extensive experience in multiplex immune-based assays. Specifically Meso Scale Diagnostics and multichannel flow cytometry including the development of gating strategies.
- Confident and proven safety when working in Biosafety Level 2 environments.
- Excellent writing and presentation skills. Accurate and appropriate data analysis and use of statistics.
- Familiar with Spotfire and Big Omics or similar visualization platforms. Fluent working with Graph Pad and Microsoft Office. Adept utilizing Flo Jo or similar.
- Responsible and reliable record keeping organization and assisting in lab management as needed.
- Very strong communicator in English language
Benefits
Health benefits
Dental plan
Disability benefits
Health care plan
Paramedical services coverage
Vision care benefits
Financial benefits
Bonus
Group insurance benefits
Life insurance
Registered Retirement Savings Plan (RRSP)
Long term benefits
Maternity and parental benefits
Other benefits
Learning/training paid by employer
On-site amenities
Paid time off (volunteering or personal days)
Compensation
$80000-$100000 per annum
Contact:
Required Experience:
Manager
Employment Type
Full-Time
