(Senior) Scientist - DMPK/PD Project Leader
Share
Job Location:
Monthly Salary:
Posted on:
07-09-2025
Vacancies:
1 Vacancy
Job Summary
At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.
The Position
This Opportunity
Support drug discovery and early development by applying DMPK/PD and modeling & simulation concepts starting from lead identification through the clinical phase.
Be the responsible DMPK/PD representative on multi-functional expert teams contributing to the evaluation of new chemical entities (NCEs).
Identify and address key DMPK liabilities for new chemical series during the Lead Identification phase.
Design and execute eADME optimization strategies to mitigate safety risks and ensure adequate exposure in preclinical safety evaluations and clinical studies
Plan (in close collaboration with technology platform-owners) ADME PK and PK/PD studies which are needed to select and characterize investigational new drugs
Integrate DMPK/PD bioanalytical and biotransformation data to address complex project challenges enabling informed and timely decision-making.
Employ translational PK/PD principles including basic modeling and simulation (e.g. PKPD PBPK and human dose/dose regimen prediction) to guide drug discovery and development activities.
Prepare scientific assessments of non-clinical DMPK information on development compounds suitable for internal program review and regulatory submissions
Expand scientific visibility and maintain effective interactions with internal and external collaborators
Who You Are
Education/Qualifications
A Ph.D. or equivalent degree in pharmaceutical sciences or other relevant bioscience discipline. Additional years of Post-doctoral and/or Industrial experience are a plus.
Ability to communicate confidently in English with colleagues and collaborators via teleconferences presentations and written reports
Job Required Competencies
Expertise on DMPK project leader
In-depth experience with modern approaches in DMPK/PD used to support drug discovery projects (in vitro in vivo and computational tools)
Background in working closely with colleagues in chemistry biology in vivo DMPK and pharmacology
Knowledge of the drug development processes the context of pharmaceutical industry
DMPK/PD based experience and track record in the pharmaceutical industry is a plus
Hands-on experiences with PBPK PK/PD and M&S techniques would be beneficial
Knowledge and familiarity with common DMPK assays and early DMPK compound screening strategies
Strong interpersonal skills and team player
Leadership Competencies
preferable
Propose and evaluate innovative DMPK/PD approaches and develop new scientific strategies within the ADME/DMPK area.
Have a highly self-motivated and innovative mindset and guide development of new assays
Build open and honest collaborations with internal and external partners (for example global colleagues CROs universities research institutes)
Good English communication and presentation skills.
Good organizational and multi-tasking abilities to ensure quality and timely delivery of the project deliverables
Who we are
A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver life-changing healthcare solutions that make a global impact.
Lets build a healthier future together.
Roche is an Equal Opportunity Employer.
Required Experience:
Senior IC
Key Skills
- IT Experience
- Order Management System
- Clinical Development
- Project Leadership
- Clinical Trials
- Research Experience
- Project Management
- Research & Development
- Microsoft Project
- LIHTC
- Sales Support
- Contracts
About Company
Petrochem is a market leader in chemical distribution and connecting chemical manufacturers and chemical users throughout the world. Petrochem provides business-to-business distribution solutions for industrial and specialty chemicals. With over10,000products and a highly diverse supp ... View more
