Scientist 2 - Research and Development
Scientist 2 - Research and Development
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Salary Not Disclosed
1 Vacancy
Job Description
Key Responsibilities:
30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides including siRNA and ASO to support both discovery portfolio and pre-portfolio projects
20% Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC addition phosphoramidites or lipids by HPLC and LCMS.
20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
5% Analyze oligonucleotides by HPLC-SEC RP-IP and Ion-Exchange Chromatography.
Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
Support integrity confirmation requests (such as concentration) by assay development and biology teams
3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
5% Ensure the supply of laboratory consumables and reagents are in stock as needed
Maintain a high level of productivity in the laboratory setting.
2% Present data and reports on project status at individual group and departmental meetings.
Qualifications
Ph.D.. with 1-3 years of experience performing progressively advanced duties at the Scientist level or the equivalent training/experience is required.
Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
Top Three Skills: Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughout analytical capabilities
Role is 100% onsite
Additional Details
- Solution & Requisition Sourcing Type : Vendor NeutralSourced
- Reason for Request : Open Position
- Critical Position : No
- Is this position safety sensitive : No
- Will this position require the handling of a controlled substance : No
- Funding or Grant Tracking : No external funding
Employment Type
Full-time
Key Skills
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