Research Associate - Marson Lab

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Description:

Who we are

The Gladstone Institutes is a leading independent not-for-profit research organization dedicated to improving human health through groundbreaking biomedical research and education. Our work spans neuroscience cardiovascular biology immunology and stem cell biology with a strong emphasis on understanding and treating disease. With approximately 600 team members including world-renowned scientists and biomedical leaders Gladstone fosters a collaborative and innovative environment. Located at the Mission Bay Campus in a state-of-the-art facility we offer competitive salaries comprehensive benefits and the resources to empower individuals to maximize their potential and make a meaningful impact on global health.

About the Role
We are seeking highly motivated Computational Research Associates (RAs) to contribute to multidisciplinary projects at the intersection of genome engineering single-cell omics and statistical genetics. Our lab has pioneered the use of cutting-edge genetic engineering technologies such as CRISPR in primary human immune cells (Shifrut et al. Cell 2018). These advances have enabled us to explore the genetic underpinnings of T cell biology (Schmidt and Steinhart et al. Science 2022; Schmidt and Ward et al. Nature 2023; Arce et al. Nature 2024).

In collaboration with the Pritchard Lab at Stanford we recently developed new approaches to interpret how regulatory networks control immune traits by integrating single-cell perturbation experiments with human genetics data (Ota et al. bioRxiv 2025). Building on these efforts we have established genome-wide CRISPR screening platforms in primary human immune cells with single-cell genomics readouts (Perturb-seq).

The RA will play a key role in analyzing large-scale Perturb-seq datasets to dissect the genetic networks that regulate T cell function and identity and to uncover their impact on complex human traits.

What you will do

• Process and analyze large-scale single-cell perturbation datasets

• Apply statistical and machine learning methods for data interpretation

• Perform integrative analyses with public datasets (e.g. scRNA-seq GWAS)

• Optimize workflows and codebases for efficient data processing

• Document and present results in written reports and lab meetings

• Contribute to a collaborative and organized research environment

What you will need

• BS/BA or MS in bioinformatics computer science biology biochemistry or related field plus 1 year of relevant experience (or equivalent combination of education and experience)

• Strong programming skills (e.g. Python R Bash)

• Experience working in a Linux environment

• Excellent organizational written and verbal communication skills

• Ability to work independently and collaboratively in a research team

• Flexibility to learn new methods and adapt to evolving research priorities

What is preferred

• Experience with omics data analysis frameworks (e.g. Scanpy/scverse DESeq2)

• Background in statistics or machine learning; familiarity with ML frameworks (e.g. scikit-learn PyTorch)

• Knowledge of molecular biology and immunology

Application Materials

• Resume/CV (include 3 references on your resume)

• Cover letter with a brief statement of research background interests and future goals

Salary Range:

RA I- $27-$31/hr.

RA II- $68640 - $80577

RA III- $75505 - $88634

Gladstone Perks & Benefits

• Peoplework with talented committed and supportive teammates within an organization that values each member of its community.

• A meaningful place to grow and learnwhether its your professional skills or scientific knowledge we have the resources and environment to advance either so you can better support Gladstones mission to drive a new era of discovery in disease-oriented science and to mentor tomorrows leaders in an inspiring and excellent environment.

• Healthy work/life balanceyou are highly engaged and productive at work because you can have time to recharge and enjoy a vibrant life outside of work.

• Compensationcompetitive salary. Title and salary will be commensurate with education and experience.

• Excellent benefitsgenerous medical dental vision retirement plan paid vacation commuter benefits access to free shuttle transportation.
  

Gladstone is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race color sex religion national origin ancestry age marital status medical condition physical or mental disability veteran status sexual orientation or any other non-job related characteristic. We make all employment decisions so as to further this principle of equal employment.