Senior Scientist, Cell Therapy Characterization
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Job Location:
Malvern, PA - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at
Job Function:
Discovery & Pre-Clinical/Clinical DevelopmentJob Sub Function:
Biotherapeutics R&DJob Category:
Scientific/TechnologyAll Job Posting Locations:
Malvern Pennsylvania United States of AmericaJob Description:
About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.
Learn more at are searching for the best talent for a Senior Scientist Cell Therapy Characterization to be located in Malvern PA.
You will be responsible for:
Leading the development optimization and execution of assays to characterize cytokine secretion in CAR-T drug products
- Design and implement cell-based functional assays to assess cytokine release profiles including:
- Potency assays with poly cytokine readouts
- ELISA
- Assess specific multiplex cytokine assay platforms (i.e. Luminex MSD Ella)
- Intracellular Cytokine Staining (ICS) via flow cytometry
- Correlate cytokine profiles with CAR-T functionality phenotype and efficacy
- Work collaboratively on a matrix environment supporting and mentoring team members.
- Communicating complex technical concepts to partners.
- Accurately capturing data in a timely manner including maintenance of detailed records in compliance with applicable cGMP safety and environmental requirements.
Qualifications / Requirements:
Education:
- A minimum of a Bachelors degree is required. An advanced degree (Masters PhD) is preferred.
Experience & Skills:
- At least 6 years of relevant pharmaceutical or industry experience is required with a Bachelors degree. 4 years of experience is required for a Masters Degree and 2 years of with a PhD.
- Expertise with T cell cell-based bioassays such as in vitro tumor killing cytokine secretion proliferation including assay design and method robustness required.
- Expertise using specific sandwich ELISA based methods such as MSD
- Preferred experience with method qualification including knowledge of ICHQ14 and ICHQ2(R2).
- Preferred experience in conventional flow cytometry
- Strong analytical problem solving planning and organizational skills is required.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation please email the Employee Health Support Center () or contact AskGS to be directed to your accommodation resource.
#LI-Onsite
Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Mammalian Cell Culture
- Biochemistry
- Assays
- Protein Purification
- Research Experience
- Next Generation Sequencing
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
