Protein Expression and Purification Scientist
Protein Expression and Purification Scientist
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Job Description
Job Description
Our Company is on a quest for cures and is committed to being the worlds premier most research-intensive biopharmaceutical company. Our Companys Research Laboratories is a true scientific research facility of tomorrow and will take Our Companys leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.
We are seeking a highly motivated scientist with experience in a discovery pharmaceutical setting. The ideal candidate will have exceptional organizational and interpersonal skills along with a solid background in the life sciences. The selected individual will join the Discovery Biologics group at Our Company and will primarily be responsible for the expression and purification of therapeutic protein and antibody candidates. Additionally complex multi-step purification of difficult to generate proteins will be needed. The candidate will be expected to interface with other functional groups including in vitro display molecular biology and protein engineer functions and the downstream analytical group. Good communication skills and the ability to present scientific data to multi-functional teams are critical.
What you will do:
Contribute to our Discovery Biologics pipeline by generating high quality antigens antibodies and other fusions proteins.
Collaborate with upstream and downstream colleagues to enable continuous process improvements
Serve as a functional area representative on program teams
Promote the external reputation of our Discovery Biologics organization
What you will need to be successful in this role:
Qualifications and Experience:
Bachelors in Biochemistry or related discipline with 2 years of hands-on post-graduate industry experience or Masters in Biochemistry or related discipline with hands-on industry experience
Excellent attention to detail and record keeping in electronic lab notebooks
Excellent communication and collaboration skills
Required Skills:
Experience in transient protein expression from mammalian cell lines (HEK and CHO)
Experience in multiple techniques of antibody/protein purification including affinity ion exchange chromatography and preparative size exclusion
Basic protein analytics including analytical SEC and SDS-PAGE
Technical background and hands-on experience with aseptic cell culture techniques
Preferred skills:
Experience with AKTA FPLC purification workflows strongly preferred
Experience in protein design and engineering with focus on antibodies including bispecific/multispecific formats
Experience generating challenging to express proteins including but not limited to multispecific antibodies membrane proteins and highly glycosylated antigens
Experience in other characterization workflows such as binding (SPR) or functional (cell based) assays
Experience with liquid handling systems (Hamilton TECAN Lynx) a plus
As an Equal Employment Opportunity Employer we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race color age religion sex sexual orientation gender identity national origin protected veteran status disability status or other applicable legally protected a federal contractor we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws visit:
We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences perspectives skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas broad experiences backgrounds and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.
Learn more about your rights including under California Colorado and other US State Acts
#EligibleforERP
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race color age religion sex sexual orientation gender identity national origin protected veteran status disability status or other applicable legally protected a federal contractor we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws visit:
We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences perspectives skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas broad experiences backgrounds and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.
Learn more about your rights including under California Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5 2023 employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week Monday - Thursday although the specific days may vary by site or organization with Friday designated as a remote-working day unless business critical tasks require an on-site Hybrid work model does not apply to and daily in-person attendance is required for field-based positions; facility-based manufacturing-based or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.
The salary range for this role is
$96100.00 - $151200.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive if applicable.
We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.
Employee Status:
RegularRelocation:
No relocationVISA Sponsorship:
NoTravel Requirements:
No Travel RequiredFlexible Work Arrangements:
Not ApplicableShift:
Not IndicatedValid Driving License:
NoHazardous Material(s):
OEB4 Bispecific agonistsRequired Skills:
Affinity Chromatography Anion Exchange Chromatography Automated Liquid Handling Systems Biochemistry Biophysical Characterization Cell Cultures Cell Culture Techniques Chromatography Communication Detail-Oriented Flow Cytometry High-Throughput Screening Mammalian Cell Culture Molecular Biology Molecular Biology Techniques Protein Engineering Protein Expression Protein Purifications Social Collaboration Therapeutic ProteinsPreferred Skills:
Antibodies Antibody Production Assay Biologics DNA Purification Recombinant ProteinsJob Posting End Date:
08/9/2025*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Employment Type
Full-Time
