Associate Principal Scientist (Computational), Process & Product Modeling - Large Molecules
Associate Principal Scientist (Computational), Process & Product Modeling - Large Molecules
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$ 139600 - 219700
1 Vacancy
Job Description
Job Description
Join our Companys Process & Product Modeling Team as an Associate Principal Scientist where you will lead the development of advanced computational models that accelerate the development and commercialization of biologics vaccines sterile liquids and other large-molecule therapies. This role offers a unique opportunity to apply your expertise to optimize complex manufacturing processes and directly impact patient health worldwide.
The initial focus of this role will be on downstream processes such as mechanistic chromatography modeling filtration end-to-end process flowsheets and engineering models (mass momentum energy transport chemical/biochemical reaction kinetics digital twins etc.) applicable to biologics and vaccines. Experience in these modeling methods is desired but candidates with willingness and capability to grow in these areas are also encouraged to addition the successful candidate will have opportunities to grow their knowledge into new areas including model-based process controls plant and process-economics (including facility fit cadence scheduling and cost optimization) bioreactor kinetics and metabolomics population balance models data driven models digital twin and other modeling approaches.
Responsibilities:
Collaborate closely with multidisciplinary scientists and engineers to create end-to-end predictive models that support drug substance and drug product manufacturing operations.
Develop and apply mechanistic and data-driven models especially chromatography and including filtration process flowsheets process economics and digital twins to solve real-world manufacturing challenges encountered during commercialization of new biologics and vaccines.
Drive innovation by championing computational tools that reduce costs minimize experimental batches shorten timelines and improve product quality and process robustness. Communicate complex modeling insights clearly to project teams and leadership translating results into actionable experimental and manufacturing strategies.
Lead the deployment of computational solutions using commercial software open-source tools and proprietary models you help develop.
Work independently with minimal supervision managing multiple projects and timelines effectively.
Present your work at internal meetings scientific conferences and contribute to publications.
Lead collaborations with external partners such as universities research organizations and contract manufacturing organizations (CMOs/CDMOs) to advance modeling capabilities.
Locations:
West Point PA Rahway NJ Greater Dublin Area Ireland
Required Qualifications:
PhD with 4 years or MS with 8 years of relevant experience in Chemical Biochemical Mechanical Biological Pharmaceutical Engineering or related fields.
Strong research background in computational modeling applied to large-molecule biologics manufacturing.
Expertise in one or more of the following: mechanistic chromatography modeling (preferred) end-to-end flowsheet/digital twin modeling plant/process economics bioreactor kinetics population balance models engineering transport models or data-driven modeling.
Experience with relevant software tools (e.g. GoSilico CADET SuperPro ASPEN Plus gPROMS BioSolve Dynochem). Proficiency in programming languages such as Python (preferred) Matlab C/C or R.
Excellent organizational interpersonal and communication skills.
Proven ability to work effectively in cross-functional teams.
Industrial or relevant research experience with biologics vaccines or sterile liquid manufacturing processes. Candidate with strong modeling and computational experience in other process industries will also be considered.
Preferred Qualifications:
Demonstrated success in applying modeling outcomes in commercial and cGMP environments.
Familiarity with regulatory filings (BLAs NDAs) and Chemistry Manufacturing and Controls (CMC) processes.
Experience with high-performance computing.
Strong publication presentation or patent record.
Knowledge of statistical software (Minitab JMP) and other related modeling techniques such as machine learning (ML) or artificial methods (AI) computational fluid dynamics (CFD) etc.
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U.S. Hybrid Work Model
Effective September 5 2023 employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week Monday - Thursday although the specific days may vary by site or organization with Friday designated as a remote-working day unless business critical tasks require an on-site Hybrid work model does not apply to and daily in-person attendance is required for field-based positions; facility-based manufacturing-based or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.
The salary range for this role is
$139600.00 - $219700.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive if applicable.
We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance
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Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.
Employee Status:
RegularRelocation:
DomesticVISA Sponsorship:
YesTravel Requirements:
10%Flexible Work Arrangements:
HybridShift:
1st - DayValid Driving License:
NoHazardous Material(s):
n/aRequired Skills:
Adaptability Adaptability Biochemical Analysis Bioprocessing Communication Computational Fluid Dynamics (CFD) Computational Fluid Dynamics (CFD) Simulation Data Analysis Decision Making Detail-Oriented High Performance Computing (HPC) Maintenance Supervision Manufacturing Processes Manufacturing Process Validation Manufacturing Quality Control Manufacturing Scale-Up MATLAB Mentorship Open-Source Open Source Software (OOS) Pharmaceutical Manufacturing Pharmaceutical Process Engineering Process Improvements Protein Purifications Python (Programming Language) 5 morePreferred Skills:
Job Posting End Date:
08/16/2025*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Required Experience:
Staff IC
Employment Type
Full-Time
