Apprentice in Micellar Chemistry
Apprentice in Micellar Chemistry
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Job Description
Context & apprenticeship subject: At Evotec a world leading R&D partnering organization we are committed to reduce the environmental impact of our activities by adopting the green chemistry principles (1). We design chemical products and processes that reduce or eliminate the use or generation of hazardous substances. Green chemistry applies across the life cycle of a chemical product (from design to disposal). Guided by this principle we recently developed a new working group specialized in micellar chemistry. The goal is to replace commonly used CMR solvents (DCM DMF dioxane toluene etc) by water. However the use of water as the only solvent can be complicated mainly due to the solubility of organic reagents. This is the reason why in the early 2000s some research groups have developed surfactants for organic chemistry (2) enabling reactions to be carried out in water inside these micelles the so called micellar chemistry.
The aim of this apprenticeship is to further develop micellar chemistry at Evotec. To achieve this the student would have 3 surfactants at his/her disposal: TPGS-750-M HPMC and SPGS-550-M also known as Nok (3). Those surfactants will be widely used for different types of reactions such as pallado-catalyzed cross couplings reductions amide couplings etc
(1) Anastas P. T.; Warner J. C. Green Chemistry: Theory and Practice Oxford University Press: New York1998 30 By permission of Oxford University Press
(2) a) Hedouin G. Ogulu D. Kaur G. Handa J. Chem. Commun. b) Lipshutz B.H. Gallou F. Handa S. ACS Sustainable Chem Eng.
(3) a) Fox R. Bailey J. D. Obligacion J. V. et al. Org. Process Res. Dev.b) Borlinghaus N. Wittmann V. Braje W. M. Current Opinion in Green and Sustainable Chemistryc) Klumphu P. and Lipshutz B. H. J. Org. Chem.
Candidate profile: The candidate must be enrolled in a professional bachelors masters or engineering program that includes a work-study (apprenticeship) component. and possess solid skills in organic chemistry. The candidate is expected to demonstrate a keen interest in green chemistry and in developing more sustainable solutions. He/she should be familiar with classical characterization techniques (LCMS TLC NMR...) have a strong interest in research innovation and demonstrate autonomy and initiatives.
FR : Dans le cadre de sa politique Diversit Evotec tudie comptences gales toutes les candidatures dont celles des personnes en situation de handicap.
ENG : In the frame of our Diversity policy Evotec considers with equal competences all applications including people with disabilities.
Employment Type
Full-Time
