Scientist / Senior Scientist im Bereich TSRS Nonclinical
Scientist / Senior Scientist im Bereich TSRS Nonclinical
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Job Description
Career Category
ScientificJob Description
WE ARE LOOKING FOR YOU
Amgen Research (Munich) GmbH one of Amgens state-of-the-art research hubs located in the south of Munich and home to approximately 170 employees is currently seeking a highly motivated and qualified:
Scientist / Senior Scientist (m/f/d)
Department: TSRS Nonclinical
Employment Type: Full-time Fixed-term (3 years)
Start Date: As soon as possible
We are seeking a highly skilled and motivated scientist to join our Portfolio Pharmacology and Data Sciences Department at the Scientist/Sr Scientist level. The successful candidate will conduct advanced research in the areas of 3D cell culture and organ-on-chip systems creating in vitro cellular models and relevant assays for the safety evaluation of new drug candidates.
This role can be positioned either on GCF Level 5-1 (Scientist) or 5-2 (Senior Scientist) depending on professional qualification
and experience.
TASKS:
Develop and implement new in vitro and ex vivo methods to support the development of New Approach Methodologies (NAMs) for nonclinical safety assessment.
Application of 3D cell culture models (organoids/organs-on-a-chip technologies)that replicate various human organs (e.g. lung lymph node liver pancreas blood vessels skin) and their associated diseases (e.g. cancer autoimmunity) for drug screening and safety assessment applications.
Characterization of 3D cell culture models using fluorescence microscopy flow cytometry or gene/protein expression.
Qualifying 3D cell culture models for a particular use by quantifying their ability to predict known clinical outcomes.
Conducting relevant cellular/molecule functional in vitro assays on the efficacy and toxicity of potential drug candidates (e.g. antibodies) utilizing plate-based immunoassays FACS and cell-based imaging with minimal supervision.
Develop hypotheses and design experimental plansto propose creative and novel solutions execute experiments and analyze and interpret results.
Collaborate cross-functionallywith various scientific teams sharing ideas and proposing solutions for scientific and clinical challenges during regular group meetings and internal seminars.
Engage in appropriate training of lab personnel and lab maintenance including equipment maintenance and ordering supplies.
Manage projects independentlyand contribute to their intellectual advancement.
Stay updated on current literaturein organoids and organs-on-a-chip technology and related fields.
Qualifications and requirements:
Masters Degree with 3 years of experience or PhD degree in cell biology immunology biochemistry or related fields.
In-depth knowledge and hands-on experience with cell cultures such as immortalized cells particularly in 3D cell culture models and organs-on-a-chip technologies including design characterization and validation as well as in cell-based assays molecular biology immunology and biochemical techniques.
Skilled in biomarker detectiontechniques including ELISA and ELISPOT.
Strong analytical and problem-solving skills.
Excellent verbal and written communication skillsin English and German with a strong willingness to collaborate in a global environment.
Preferably direct experience developing organoids or organs-on-a-chip model within academia or a model development company.
WHAT WE OFFER TO YOU
Flexible working hours
38-hour work week
30 days of annual vacation
Additional leave for special occasions (e.g. wedding relocation etc.)
Access toEGYM Wellpassfor fitness and wellness
Busuulanguage learning app subscription
Meal subsidy of 1.50 per day
Company pension plan:
4% of monthly base salary up to the social security contribution ceiling
An additional 7% of monthly base salary above the contribution ceiling
Childcare allowance of up to 120 per month
Employee recognition program (awards ranging from 50 to 450)
Employee Assistance Program (EAP) for personal and professional support
Required Experience:
Senior IC
Employment Type
Full-Time
