Sr. Director, Quantitative Pharmacology & Pharmacometrics (Hybrid or Remote)
Sr. Director, Quantitative Pharmacology & Pharmacometrics (Hybrid or Remote)
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$ 206200 - 324600
1 Vacancy
Job Description
Job Description
The Quantitative Pharmacology and Pharmacometrics (QP2) department drives model-informed drug discovery and development (MIDD) to routinely enable efficient drug discovery/development and/or regulatory decisions. The Pharmacometrics group within QP2 brings an experienced leadership team deep modeling expertise and state-of-the-art modeling approaches across multiple therapeutic areas and modalities to drive portfolio impact from discovery through life-cycle management. The team is externally visible and continues to be at the leading edge of building innovative tools. With MIDD as an essential component of decision-making at our Company this position offers an opportunity for the Pharmacometrics leader to drive pipeline impact and lead a talented group of pharmacometricians.
This Senior Director is expected to be an experienced pharmacometrician with a strong understanding of the integrated strategic elements of drug discovery and development and the ability to incorporate Modeling and Simulation (M&S) tools in decision making to drive pipeline impact. The Senior Director will take on primary responsibilities for identifying emerging areas of pharmacometric innovation and leading QP2 efforts to strengthen our pharmacometric capabilities on a continuous basis. The Senior Director will be accountable for directing a team of pharmacometricians with diverse backgrounds and bringing subject matter expertise related to model informed drug discovery and development for programs.
The Senior Director in Pharmacometrics should provide strategic leadership for pharmacometrics through the following responsibilities and skills:
Guide a team of approximately 5-10 pharmacometricians to achieve results on major program drivers by identifying and implementing quantitative approaches (for e.g. translational PK/PD models population pharmacokinetic models exposure-response models quantitative system pharmacology (QSP) and disease progression models clinical trial simulations comparator modeling) that seek to improve cycle time cost/size and number of trials implementation of tools and framework for driving Go/No Go decisions on programs and rapid regulatory approvals
Foster collaboration within QP2 to achieve results remove barriers on portfolio or scientific priorities
Evaluate and maintain appropriate quality systems and IT infrastructure for QP2 to support emerging capabilities
Responsible for priority-setting performance management hiring and retention talent development/management for direct reports
Identify resource needs and contribute to resource allocation internally and through management of business operations and outsourcing budgets
Provide functional representation on committees task forces or initiatives spanning beyond QP2
Initiate and manage external collaborations to develop new methodologies and lead our external outreach to the scientific pharmacometrics community
Required Experience:
Ph.D. or equivalent degree with 10 years of experience where experience means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia
Educational background in pharmacometrics pharmaceutical sciences mathematics statistics/biostatistics computational biology/chemistry chemical/biomedical engineering or a related field
At least 10 years of discovery/drug development/regulatory experience
Deep expertise in pharmacometrics (e.g. population PK and PK/PD analyses model-based meta-analysis dose-response and exposure-response analyses disease modeling trial simulation optimal study designs strategic decision analyses economic modeling) with ability to understand how MIDD can drive portfolio and regulatory decisions
Extensive experience in developing quantitative strategies for impacting pipeline decisions
Good interpersonal and communication skills that ensure teamwork and productive interactions among diverse personalities/areas of expertise
The remote position is only applicable for those that are not within commutable distance to primary sites noted in posting. If commutable the position will be hybrid. Please note that standard commute is (less than) <50 miles.
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#QP2
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Current Contingent Workers apply HERE
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U.S. Hybrid Work Model
Effective September 5 2023 employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week Monday - Thursday although the specific days may vary by site or organization with Friday designated as a remote-working day unless business critical tasks require an on-site Hybrid work model does not apply to and daily in-person attendance is required for field-based positions; facility-based manufacturing-based or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.
The salary range for this role is
$206200.00 - $324600.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive if applicable.
We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.
Employee Status:
RegularRelocation:
DomesticVISA Sponsorship:
YesTravel Requirements:
25%Flexible Work Arrangements:
Not ApplicableShift:
Not IndicatedValid Driving License:
NoHazardous Material(s):
n/aRequired Skills:
Clinical Trial Designs Clinical Trial Designs Clinical Trials Data Analysis Data Engineering Data Modeling Data Visualization Disease Models Dose Response Analysis Drug Development Drug Discovery Process In Vivo Disease Models Machine Learning Modeling Software Multiple Therapeutic Areas Pharmaceutical Development Pharmaceutical Sciences Pharmacology Pharmacometrics PKPD Modeling Population Pharmacokinetics Quality Management Regulatory Applications Stakeholder Relationship Management Strategic Leadership 1 morePreferred Skills:
Job Posting End Date:
07/18/2025*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Required Experience:
Director
Employment Type
Full-Time
