Sr Scientist I/II Informatics - Peptide Design
Sr Scientist I/II Informatics - Peptide Design
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Salary Not Disclosed
1 Vacancy
Job Description
AbbVie seeks a knowledgeable self-motivated and creative scientist for cyclic peptide design in for computational chemistry / drug discovery. The selected candidate will join our Computational Drug Discovery group within the Discovery Research organization. AbbVie has recently gained the capability to synthesize millions of custom cyclic peptide sequences in a programmable manner and to individually characterize their interaction with a desired protein partner. The candidate will be expected to leverage this opportunity to computationally design novel cyclic peptides as an entry-point to this platform.
The candidate will have the opportunity to develop and advance physics-based modeling as well as AI/ML technologies at the heart of computer-aided peptide design. The candidate should have broad experience with computational techniques with a focus on the state-of-the-art methods in machine learning applied to chemical and biological data. The key responsibilities of this position are to identify develop optimize validate and deploy innovative methods for modeling cyclic peptides and their interactions with proteins. The candidate should have a working knowledge of chemistry and the ability to work collaboratively with a broad variety of disciplines including other members of our internal computational chemistry and cheminformatics groups to accelerate drug discovery from hit identification through candidate selection.
You will have access to state-of-the-art modeling simulation and machine learning technologies as well as computing infrastructure and be able to leverage rich collections of data to accelerate drug discovery in a fast-paced and creative environment.
Key Responsibilities:
- Developing implementing and deploying programs and computational solutions employing Machine Learning/Deep learning and Cheminformatics
- Ability to implement debug and maintain computational tools in common programming languages (Python etc) and proficiency with cloud computing capabilities
- Familiarity with modern deep learning architectures including GNN CNN RNN Transformer GCNN and MPNN and machine learning paradigms such as generative models GAN and active learning
Qualifications :
Qualifications:
- Bachelors Degree or equivalent education and typically 10 years of experience Masters Degree or equivalent education and typically 8 years of experience PhD and no experience necessary.
- MS or PhD in Chemistry/Computer Science/Machine Learning/Cheminformatics/Chemical Engineering or related education with experience developing machine learning models related to chemical and biological data preferred.
- Expertise in AI/ML-enabled molecular generation pose generation sequence design and/or affinity prediction are preferred
- Strong analytical and problem-solving skills with demonstrated ability to think critically and creatively and provide solutions both individually and collaboratively with internal experts to develop and optimize the computational discovery infrastructure including cloud resources
- Excellent ability to communicate clearly and concisely with colleagues and collaborators including an ability to explain complex ideas to non-specialists
- Strong programming skills in Python and experience with data science stack including numpy pandas scikit-learn and other related scientific libraries
- The level of the position will be determined by the skill set of the candidates
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more visit & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:
No
Employment Type :
Full-time
Employment Type
Full-time
