Postdoctoral Research Associate (Functional Genomics) - Psychiatry
Postdoctoral Research Associate (Functional Genomics) - Psychiatry
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Job Description
Position Summary
Functional Genomics of circular RNAs in Alzheimers Disease.The Cruchaga Lab member of the NeuroGenomics and Informatics Center is recruiting a motivated creative self-driven Postdoctoral Research Associate to functionally characterize the role of circular RNAs (circRNAs) in Alzheimers disease (AD). CircRNA is a new category of non-coding RNAs that result from backsplicing events and are highly expressed in the central nervous system especially in synapses. Recently our group identified significant associations between circRNA expression and AD diagnosis clinical dementia and neuropathological severity.
The Postdoctoral Research Associate will be mentored by Dr. Carlos Cruchaga and will focus on the identification and modification of circRNAs in in vitro models of Neurodegenerative Diseases. Towards this end various cell lines combined with molecular cellular biochemical and pharmacological methods will be utilized to functionally characterize AD-associated circRNAs for subsequent transcriptomic and proteomic analyses. The new Postdoctoral Research Associate will work in a collegial environment and join a multidisciplinary diverse team in a well-stablished well-funded research group currently 35 dynamic members developing bioinformatics analyzing multi omics data and performing functional genomics analyses to explore the frontiers of AD.
Job Description
Primary Duties & Responsibilities:
Information on being a postdoc at WashU in St. Louis can be found at Publications on the Subject:
Dube U et al. Nat Neurosci. 2019. PMID: Chen HH et al. Acta Neuropathol. Commun. 2022 PMID: Bellenguez C et al. Nat Genet. 2022 PMID: Ibanez L. Genes (Basel). 2021. PMID:.
Trains under the supervision of a faculty mentor including (but not limited to):
- Assists with grant preparation and reporting.
- Prepares and submits papers on research.
- Assists in the design of research experiments.
- Evaluates research findings and assists in the reporting of the results.
- Maintains conformity with ethical standards in research.
- Maintains compliance with good laboratory practice including the maintenance of adequate research records.
- Engages in open and timely discussion with mentor regarding possession or distribution of material reagents or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
- Collegial conduct towards co-trainees staff members and members of the research group.
- Adherence to all applicable University policies procedures and regulations. All data research records and materials and other intellectual property generated in University laboratories remain the property of the University.
Working Conditions:
This position works in a laboratory environment with potential exposure to biological and chemical individual must be physically able to wear protective equipment and to provide standard care to research animals.
Salary Range:
Base pay is commensurate with experience.
The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.Required Qualifications
Education:
Ph.D. M.D. Or Equivalent Terminal Or Doctoral Degree.
Certifications:
Work Experience:
Skills:
Drivers License:
More About This Job
Preferred Qualifications:
- Strong background and demonstrated experience in one or more of the following areas: cell biology molecular biology biochemistry genetics or RNA biology.
- Hands-on experience in mammalian cell culture Northern and Western blotting ELISA qPCR RNA/DNA delivery (e.g. mRNA siRNA ASO lentivirus technology transient transfection loss/gain of function experiments) immunocytochemistry light and confocal experience with induced pluripotent stem cell (iPSC) cultures is advantageous.
- Knowledge of flow cytometry cell sorting high-throughput screening and cell-based screening (e.g. luciferase assays high-content imaging massively parallel/multiplexed assays etc.) is desirable.
- Ability to interpret and discuss experiments and critically contribute to writing of manuscripts and grant proposals is expected.
- Well-organized able to multi-task with excellent lab bench skills.
- Able to work independently and as part of a team.
- Prior experience in AD or neurodegenerative diseases research is desirable.
Preferred Qualifications
Education:
No additional education beyond what is stated in the Required Qualifications section.
Certifications:
Work Experience:
Skills:
Questions
For frequently asked questions about the application process please refer to our External Applicant FAQ.
Accommodation
If you are unable to use our online application system and would like an accommodation please emailor call the dedicated accommodation inquiry number at and leave a voicemail with the nature of your request.
All qualified individuals must be able to perform the essential functions of the position satisfactorily and if requested reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job absent undue hardship.Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and as applicable for the position other background checks drug screen an employment and education or licensure/certification verification physical examination certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status full-time equivalent (FTE) workload and weekly standard hours. Please visit our website at to view a summary of benefits.EEO Statement
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the Universitys policy to provide equal opportunity and access to persons in all job titles without regard to race ethnicity color national origin age religion sex sexual orientation gender identity or expression disability protected veteran status or genetic information.Washington University is dedicated to building a community of individuals who are committed to contributing to an inclusive environment fostering respect for all and welcoming individuals from diverse backgrounds experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.Required Experience:
IC
Employment Type
Full-Time
