Principal Scientist Medicinal Chemistry - San Diego, CA
Principal Scientist Medicinal Chemistry - San Diego, CA
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
$ 148000 - 179300
1 Vacancy
Job Description
ATTENTION MILITARY AFFILIATED JOB SEEKERS- Our organization works with partner companies to source qualified talent for their open roles. The following position is available toVeterans Transitioning Military National Guard and Reserve Members Military Spouses Wounded Warriors and their Caregivers. If you have the required skill set education requirements and experience please click the submit button and follow the next steps. Unless specifically stated otherwise this role is On-Site at the location detailed in the job post.
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here uniquely interesting work happens every day in every department. From optimizing a production line to the latest breakthroughs in cell therapy this is work that transforms the lives of patients and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope alongside high-achieving teams. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits services and programs that provide our employees with the resources to pursue their goals both at work and in their personal lives.
Job Description
The Principal Scientist will design and synthesize novel chemical constructs as potential new RPT therapies for cancer treatments. This position will require a highly motivated and an experienced medicinal chemist with strong synthetic organic and/or peptide chemistry skills. The role will offer an opportunity to work as functional lead on multiple projects ranging from target selection through candidate nomination stages and can be expected to lead early-stage projects in an interdisciplinary setting. The role is highly technical and will need a person who enjoys leading from the bench with high productivity and data analysis skills and a comfort level in working under tight timelines. The role requires an ability and willingness to manage both internal and external chemistry personnel.
Job Responsibilities
Essential duties and responsibilities include the following. Other duties may be assigned.
Design and synthesize small molecule/peptide compounds in support of SAR campaigns for pipeline projects.
Lead SAR efforts on assigned projects design and synthesize key target molecules to assess chemical/biological hypothesis.
Work in close collaboration with interdisciplinary teams to provide functional chemistry leadership to guide programs through lead identification/optimization phases.
Work closely with biology DMPK imaging and in vitro/vivo teams to ensure that target compounds are generated in a timely manner to support the screening funnel.
Supervise the work of junior scientists and ensure experimental rigor and high quality.
Regularly present research findings and project updates to interdisciplinary teams.
Keep abreast of the literature in the field of RPTs identify novel concepts and ideas to help advance the state of art in RPT field.
Participate in intellectual property filings and the preparation of publications and presentations.
Identify external partners KOLs outside expertise that will help advance the pipeline.
Serve as the scientific lead for external partnerships collaborations and lead scientific projects through outsourcing if needed.
Adhere rigorously to safety guidelines regulatory standards and company policies and ensure a safe working environment.
Education and Experience
PhD in synthetic organic peptide or medicinal chemistry with 5 years of experience or MS 10 years in pharmaceutical/biotech R&D environments demonstrating successful accomplishments and progressive leadership and broadening responsibilities.
Experience in working on targeted cancer therapy modalities such as RPTs ADCs PDCs is highly desirable.
Skills and Qualifications
Experience in leading small molecule/peptide projects from screening hit to development candidate.
Demonstrated ability to supervise and effectively guide the work of junior scientists and has managed external chemistry resources.
Strong interpersonal organizational and communication skills and ability to motivate and drive productivity in small company environments. Prior experience as a chemistry leader or functional leader on interdisciplinary team is critical.
Well versed in modern synthetic organic/peptide/med chem principles and demonstrated track record of high productivity and achievements in the lab.
High scientific curiosity and a learning mindset coupled with strong technical problem-solving skills and strong understanding of the concepts of drug design SAR analysis ADME/PK is important.
The ability to share data and collaborate with cross functional team members is critical as is the ability to effectively interpret data and plan experiments without supervision.
Excellent written and oral communication and presentation skills and ability to work in a fast-paced dynamic and collaborative environment.
Physical Demands
While performing the duties of this job the employee is regularly required to sit reach with hands and arms and talk or hear. The employee must occasionally lift and/or move up to 30 pounds. Specific vision abilities required by this job include close vision and distance vision.
This is a position that requires working in a laboratory environment protective clothing gloves and safety glasses are required while working in a laboratory environment.
Work Environment
The noise level in the work environment is usually moderate.
The starting compensation for this job is a range from $148000 - $179300 plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job such as required skills and where the job is performed. Final individual compensation will be decided based on demonstrated experience.
Required Experience:
Staff IC
Employment Type
Full Time
