Senior Scientist, Translational PKPD Modeling & DMPK (Oncology)
Senior Scientist, Translational PKPD Modeling & DMPK (Oncology)
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Job Description
Senior Scientist/ Associate Principal Scientist Translational PKPD Modeling & DMPK (Oncology)
Waltham MA
Description:
AstraZeneca is a global biopharmaceutical company driven by what science can do. We are dedicated to discovering developing and delivering innovative meaningful medicines and healthcare solutions that enrich the lives of patients. The vision of AstraZeneca Oncology is to redefine cancer redefine our solutions to cancer and restore patients lives. To achieve this we have an exciting and diverse portfolio that focuses on four scientific platforms that we believe show the greatest potential for yielding effective medicines for cancer patients. These scientific platforms include; Immuno-Oncology (IO) Tumor Drivers & Resistance (TDR) DNA Damage Response (DDR) and Antibody Drug Conjugates (ADC) and we are developing therapeutic agents across multiple modalities including; small molecules biologics Antibody Drug Conjugates (ADCs) nano-medicines and PROTACs.
The Oncology DMPK department provides drug metabolism & pharmacokinetic as well as translational PKPD modeling & simulation support to our portfolio. Translational PKPD Modeling & Simulation scientists occupy high profile visible roles within Early Oncology. We are looking for an individual who has a passion for PKPD modeling and DMPK science applied to Cancer biology.
As a Translational PKPD Modeling & Simulation scientist you will have the opportunity to drive strategy in PKPD science across our diverse portfolio. Your day-to-day role is to provide projects with expert modeling input into exploring the PK/PD/Efficacy in pre-clinical models and using these models in order to iteratively build an understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents.
The role holder will contribute to DMPK Modeling and Simulation by:
- Representing Oncology DMPK and providing overall scientific leadership for cross functional and external collaborations involving DMPK.
- Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP).
- Predicting human dose and regimen together with providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria for early clinical trials.
- Driving learning through back translation of early clinical exposure and PD data and providing prioritized future options for clinical testing.
- Leading and participating in Oncology strategic scientific initiatives and continuous improvement projects by providing expert M&S knowledge.
- Managing student and Post Doc programmes.
- Involvement in external collaborative projects with academic or cross-pharma pre-competitive groups.
- Providing disciplinary scientific leadership and presenting work through patents publications and lectures.
Essential Requirements:
PhD or equivalent degree in a discipline with a significant component of Modeling & Simulation such os systems biology quantitative pharmacology pharmacometrics chemical engineering physics pharmaceutical sciences or applied mathematics.
PhD with 0-4 years of relevant industry experience in Modeling & Simulation ideally in preclinical/translational setting or a MS degree with at least 5 years of relevant industry experience.
About The Site
The Waltham R&D site is home to our small-molecule oncology research in North America and is situated within a biopharma cluster of academic research institutions medicais centers pharmaceutical companies and biotech startups. The Boston region is consistently ranked #1 globally for biotech research investment talent recruitment and lab space.
The campus also known as the Boston BioHub is one of the largest and most dynamic life-science research hubs in the region. It is home to more than 800 scientists and experts working in nine different pharmaceutical and biotech companies. The site is also home to the AstraZeneca Incubator a program that helps emerging companies advance novel and innovative healthcare solutions to meet the needs of patients. Plenty of free parking with charging stations now available for electric vehicles and shuttle service to local transportation hubs.
Next Steps Apply today!
To be considered for this exciting opportunity please complete the full application on our website at your earliest convenience it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit please share this posting with them.
Date Posted
11-Jun-2025Closing Date
17-Jun-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Senior IC
Employment Type
Full-Time
