Master Thesis in Epigenetic Cancer Research â Department of Medicine 2, Hematology and Oncology
Master Thesis in Epigenetic Cancer Research â Department of Medicine 2, Hematology and Oncology
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Job Description
TheDepartment of Medicine 2 Hematology/ Oncologyat theGoethe UniversityHospital Frankfurtoffers the entire spectrum of diagnostics and therapy of malignant diseases as well as a research program focusing on several cancer entities. The research laboratory of Professor Thomas Oellerich is part of the Frankfurt Cancer Institute and focuses on oncogenic signaling and therapy resistance mechanisms in lymphoma and acute myeloid leukemia. ( lab is furthermore funded by the German Cancer Consortium (DKTK) which was founded in 2012 as one of the six German Centers of Excellence for Health Research (DZG). DKTK aims at bringing promising results from cancer research faster into clinical development and patient care. In the DKTK more than 20 academic research institutions and university hospitals at seven partner sites cooperate with each other and the German Cancer Research Center (DKFZ) in Heidelberg as the core center (
Your Role:
The project focuses on deciphering a novel cancer vulnerability in Lymphoma. The gene of interest is involved in ubiquitin and epigenetic signaling which appear to influence B-cell development.
- Molecular biology tasks include Western Blotting cell culture DNA-damage and replication assays flow cytometry and image-based assays.
- Genetic modification of cancer cell lines utilizing CRISPR-Cas9 and shRNA-mediated knockdowns
- State-of-the-Art advanced techniques such as proximity-labeling MassSpec proteomics RNAseq and CHIP-seq
- Data analysis figure generation and scientific presentations
- Bioinformatic analysis in R including exploratory data analysis gene set enrichment analysis and figure generation utilizing ggplot and Bioconductor packages (optional)
- Code documentation with version control using GitHub (optional)
- Enrolled in a university master program in biology biochemistry or a related discipline
- Enthusiasm and fascination for biomedical research oncology cell and molecular biology
- High motivation for experimental lab work
- Experiences in cell and molecular biological as well as biochemical lab techniques might be of advantage
- Experiences in coding languages such as R and Python arebeneficial
- Ability to work in a team sense of responsibility and proactivity
- Basic knowledge in MS Office (Word Excel)
- Due to legal regulations valid proof of measles immunity / measles vaccination is required
- Collective labour agreement TV GU
- International and cosmopolitan working environment
- Excellent tandem supervision by a PhD student (Chantal Schmidt) and a Team Leader (Dr. Niklas Dienstbier)
- Scientific education including the management of scientific literature a bi-weekly journal club good scientific presentation and publication practice
- Uniklinik-Campus Mensa Cafs
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Contact: Dr. Niklas Dienstbier (Team Lead - Mechanistic Lymphoma Research)
Phone or Email: 0or
Application Deadline: 10.07.2025
We welcome applications from candidates of all genders. Women are currently underrepresented in these positions at Universittsmedizin Frankfurt. Therefore applications from women are especially encouraged. Applicants with severe disabilities will be given preferential consideration in cases of equal personal and professional qualifications.
Employment Type
Full-Time
