Assistant Staff Scientist
Assistant Staff Scientist
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Job Description
Department Overview
Center Overview: The Cancer Early Detection Advanced Research (CEDAR) center is a collaborative institution within the OHSU Knight Cancer Institute. The Knight Cancer Institute known as one of the pioneers in personalized cancer medicine is an international leader in research and cancer treatment. At CEDAR our mission is to detect and stop lethal cancers at the earliest stage because early detection saves lives. This is an ambitious goal one that requires novelty creativity and innovation. We are comprised of biologists chemists biomedical engineers computationalists and clinicians conducting groundbreaking translational cancer research to help people maintain a high quality of life and reduce cancer mortality to create a global early detection community and to have a positive impact on the Oregon economy.
Our Commitment to Diversity: CEDAR is committed to increasing the diversity of the campus community. We are dedicated to promoting inclusion and multiculturalism by having outstanding researchers of diverse backgrounds work together on multiple projects. We encourage high-risk high-reward research projects because defeating cancer requires out-of-the-box thinking and new perspectives. Our research is milestone driven to ensure that each project is fulfilling its stated goals.
Every Knight Cancer employee is expected to embody our guiding principles:
- We act BOLDLYBreakthroughs require pushing the boundaries of science exploring new frontiers and thinking differently
- We SUPPORT each otherRespect leads to trust which leads to excellence
- We work as a CONNECTED teamWe must leverage our collective brain power to conquer cancer because no one individual can do it alone
Function/Duties of Position
This is an NIH grant funded position with Dr. Stuart Ibsen. We are developing an exciting new type of cancer diagnostic test that combines microfluidic and microarray technology to pull cancer-derived nanoparticles straight from plasma. Our long-term goal is to bring nanoparticle-based diagnostics to the clinic for the first time. We are currently hiring for 1-2 highly motivated and enthusiastic researchers with expertise in Engineering or Biology to work in some of the following general areas:
- Development of biological particle separation techniques using dielectrophoresis technology using microelectrode array chips to recover cancer-derived nanoparticles from circulation (Gustafson et al. 2021). This novel work will focus on the development and characterization of new nanoparticle recovery techniques using dielectrophoretic forces. These forces are created by microelectrode array devices that act on the unique dielectric properties of different particles (Ibsen et al. 2017). This work includes increasing particle collection efficiency understanding the types of particles that are collected and how they can be separated and developing an internal standard appropriate for different particle types. This position will utilize the high-end specialized dielectrophoresis equipment located here at OHSU. This will also involve quantitative fluorescent microscopy imaging TEM imaging immunostaining and particle characterization.
- System automation continuing development and finalization of an automated system to conduct the dielectrophoresis work. The goal is to automate the dielectrophoresis collection protocol to increase sample analysis throughput. This will involve basic robotics and automation programming in LabView.
- Cancer biomarker panel development evaluate the nanoparticle associated biomarkers that are collected for their ability to detect pancreatic cancer from plasma samples. Here the goal is to use the developed dielectrophoresis techniques to collect cancer-derived nanoparticles and evaluate their biomarkers for the ability to detect pancreatic cancer.
Selected References:
- Luna Ramona; Heineck Daniel; Hinestrosa Juan Pablo; Dobrovolskaia Irina; Hamilton Sean; Malakian Anna; Gustafson Kyle T.; Huynh Katherine T.; Kim Sejung; Ware Jason; Stimson Ella; Ross Christian; Schutt Carolyn E.; Ibsen Stuart. Enhancement of Dielectrophoresis-Based Particle Collection from High Conducting Fluids Due to Partial Electrode Insulation. Electrophoresis In Press (2023)
- Hamilton Sean; Shea Delaney; Ibsen Stuart* Brasino Michael*. Onchip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva. Electrophoresis Volume 44 Issue 3-4: pp. 442-449. (2023) *Co-corresponding authors
- Luna Ramona; Heineck Daniel P.; Bucher Elmar; Heiser Laura; Ibsen Stuart. Theoretical and Experimental Analysis of Negative Dielectrophoresis Induced Particle Trajectories. Electrophoresis Volume 43 Issue 12: pp. 1366-77 (2022) (Cover)
- Gustafson Kyle; Huynh Katherine; Heineck Daniel; Bueno Jesus; Modestino Augusta; Kim Sejung; Gower Austin; Armstrong Randall; Schutt Carolyn; Ibsen Stuart. Automated Fluorescence Quantification of Extracellular Vesicles Collected from Blood Plasma using Dielectrophoresis. Lab on a Chip Volume 21 Issue 7: pp. 1318-1332. (2021) (Back Cover)
- Sarno Benjamin; Heineck Daniel; Heller Michael J.; Ibsen Stuart. Dielectrophoresis: Developments and Applications from 2010 to 2020. Electrophoresis Volume 42 Number 5 pp. 539-564 (2021). (Cover)
- Ibsen Stuart; Wright Jennifer; Lewis Jean; Kim Sejung; Ko Seo-Yeon; Ong Jiye; Manouchehri Sareh; Vyas Ankit; Akers Johnny; Chen Clark; Carter Bob; Esener Sadik; Heller isolation and detection of exosomes and associated biomarkers from plasma. ACS Nano Volume 11 Issue 7 pp. 6641-6651 (2017).
Required Qualifications
- MD MD/PhD or a degree equivalent to a MD (such as DO MBBS MBChB) in a relevant field and 3 years of relevant post-doctoral work experience
- Specialty: Biomedical Engineering Electrical Engineering Mechanical Engineering or Biology
- Excellent communication analytical and organizational skills
- Ability to work independently and as part of a team while being collaborative in resolving problems
- Passion for science and inquiry
- Ability to synthesize ones own results and others to formulate hypotheses
- Ability to use tact and diplomacy to maintain effective working relationships
- Must possess energy and drive to coordinate multiple projects simultaneously
Preferred Qualifications
- Ability to synthesize scientific projects and communicate science to diverse audiences
Additional Details
Apply online. Please be sure to upload a Cover Letter and Resume/CV.
We offer a variety of benefits on top of joining a thriving organization:
- Medical dental and vision coverage at no or low cost to employees
- Covered 100% for full-time employees and 88% for dependents
- Several retirement plans to choose from with contributions from OHSU
- Up to 208 hours (equal to 25 full days) a year of paid time off
- Commuter subsidies
- Tuition reimbursement
- Access to group life insurance disability insurance and other supplemental benefits
- Annual Raises
- Growth/Development Opportunities
- Employee discounts to local and major businesses
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All are welcome
Required Experience:
Staff IC
Employment Type
Full-Time
