Scientist II, Bioassay Development

The Bioassay Development group at AbbVie South San Francisco CA is seeking a Scientist II to support the development and evaluation of newly discovered oncology and immunology drugs and existing clinical candidates including antibody therapeutics antibody-drug conjugates (ADCs) multi-specific biologics and other complex biologic modalities.

The selected candidate will join the Biologics Analytical Research and Development team a group of highly experienced scientists and managers who have directly enabled the development and IND submissions of 20 novel biologic drugs and the successful filing of several BLAs. You will have unique and diverse exposure to a significant breadth and depth of drug development activities numerous cross-functional interactions and opportunities to grow and develop in your scientific career.

Responsibilities:

In this lab-based role your major responsibilities will include:

• Development and optimization of complex cell-based functional assays (bioassays) and target-binding potency assays critical for the development of therapeutic antibodies antibody-drug conjugates (ADCs) multi-specific biologics and novel/complex antibody variants.  
• Collaborate with Analytical Research and Development teams to elucidate structure/function molecular characterization and interact cross-functionally with teams from Discovery CMC QC and more.
• Perform potency testing and characterization to support drug development activities and IND submissions.
• Qualify/validate/transfer potency methods to external partners and author technical documents (e.g. test methods protocols and reports) to enable regulatory submissions.
• Develop new techniques explore new approaches and technologies perform troubleshooting and optimization experiments and present your work to various cross-functional teams.

Qualifications :

• Degree in biology biochemistry cell/molecular biology or a related field with typically 7 years (BS) or 5 years (MS) of relevant industry experience
• Demonstrated experience with current binding potency assay approaches such as ELISA flow cytometry and/or other binding potency assay platforms (i.e. TR-FRET Octet etc)
• Demonstrated experience with current cell-based assay methodologies such as cytotoxicity assays reporter gene assays proliferation assays primary cell-based assays and/or effector function activity assays (i.e. ADCC CDC etc)
• Experience performing cell-based assays mammalian cell culture and/or target binding potency assays preferably in a bioassay development group within a Chemistry Manufacturing and Controls (CMC) organization.
• Experience using PRISM PLA Softmax Pro or similar data analysis software.
• Direct experience with biologics monoclonal antibodies and/or protein therapeutics is a plus
• Direct experience with potency assay optimization and troubleshooting is a plus.
• Proven ability to work in a highly collaborative cross-functional scientific environment.
• Strong verbal and written communication skills.
• Demonstrated abilities to quickly learn new skills think independently and work collaboratively in teams.
• The ideal candidate will be hard-working self-motivated detail-oriented highly organized and able to adapt quickly to changes.
• This position is an on-site role in a lab-based function. To be successful candidates must enjoy and thrive in an on-site highly collaborative lab environment with daily face-to-face cross-functional interactions between scientists.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• This is an on-site role based in AbbVies South San Francisco location. 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future. Salary: $82500 - $157500

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our short-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more visit  & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:

Work :

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