Research Associate II - Pan Group

Broad Institute

Posted on : 31-05-2025

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1 Vacancy

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Job Location

Cambridge - USA

Monthly Salary

Not Disclosed

Salary Not Disclosed

Vacancy

1 Vacancy

Posted on : 31-05-2025

Job Description

General information

Location

Cambridge MA

Ref #

42360

Job Family

Research

Date published

27-May-2025

Time Type

Full time

Description & Requirements

About the Stanley Center:

Reducing the burden of serious mental illness through research theStanley Centeraims to exploit the most advanced technologies for human genetic analysis in order to understand disease mechanisms for psychiatric disorders identify potential biomarkers and ignite needed progress in therapeutics. Our goal is to derive biological insights from disease associated genes contribute to new understandings of pathogenesis the identification of biomarkers and above all new treatments.

Job Description

The Stanley Center therapeutics group is seeking a candidate that will support the in vivo characterization of novel therapeutics developed here at the Broad institute to treat the unmet needs of schizophrenia. The position will be imbedded within the Stanley Center therapeutics group that combines genetics medicinal chemistry high-throughput technologies with animal model systems. The Broad Institute provides a vibrant research environment with close links to MIT Harvard and the Harvard-affiliated hospitals across Boston. The candidate will work with senior researchers to develop validate and subsequently perform rodent animal behavioral assays to characterize the effects of novel small molecule compounds targeting schizophrenia risk genes and associated pathways. The candidate will interact intensively with biologists electrophysiologists chemists and computational scientists. The candidate will spearhead the following projects:

CHARACTERISTIC DUTIES

Stereotaxic surgery for tethered and wireless EEG
Optimize and perform in vivo rodent behavioral phenotyping of novel small molecules that target ion channels GPCRs and other druggable proteins relevant for schizophrenia and other psychiatric disorders
Attend and present at multidisciplinary team meetings to share results plan projects and experiments and ensure that projects support team goals and contribute to scientific publications
Rodent tissue harvesting
Troubleshoot to resolve problems and participate in new technology evaluation development and implementation
Routine rodent colony maintenance
Document compile and analyze experimental data
Maintain detailed experimental records documentation and written protocols
Attend and present at Stanley Center and Broad-wide presentations
May perform other duties as assigned

QUALIFICATIONS

B.S. in biology neurobiology animal psychology molecular/cellular biology or a related field with at least 2 years related animal behavior experience
Must be comfortable handling mice and have prior lab experience in maintaining mouse colonies and performing in vivo rodent behavior necessary
Prior experience performing stereotaxic surgery strongly preferred
Outstanding personal initiative and communication skills
Must be able to work independently and on multidisciplinary project teams
Working closely with computational biologists or experience running custom python scripts preferred but not required
Exceptional organizational and time management skills lab notebook practices and attention to detail
Curiosity to learn new things and a passion to make a difference in the lives of patients by advancing novel treatments for psychiatric diseases.
Must be willing and able to develop and shift plans in service of a rapidly changing environment and troubleshoot to solve problems

Required Experience:

Employment Type

Full Time

Company Industry

Key Skills

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About Company

Broad Institute

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