Sr. Scientist â Discovery Proteomics - South San Francisco, CA
Sr. Scientist â Discovery Proteomics - South San Francisco, CA
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$ 177113 - 177113
1 Vacancy
Job Description
At Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.
Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology Inflammation General Medicine and Rare Disease we reach millions of patients each year. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.
Our award-winning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Scientist Discovery Proteomics
What you will do
Lets do this. Lets change the world. In this vital role you will part of the Discovery Proteomics team. We are seeking a Scientist with expertise in liquid chromatography/mass spectrometry-based proteomics to work in South San Francisco. The team develops and implements proteomic technologies for Amgens early discovery pipeline programs and technology platforms. In this role the Scientist will contribute to both discovery and targeted proteomic analyses for cell surfaceomics proximity labeling target validation and mechanism-of-action studies. Expertise in modern mass-spectrometry based proteomic technologies and cell surface protein enrichment methods is required. Additional responsibilities include technology innovation and implementing methodologies to advance Amgens early discovery-stage therapeutic candidates.
This role will enable Amgens preclinical pipeline through delivery of innovative technologies and technical expertise.
Responsibilities
Design and implement complex proteomics workflows including sample preparation liquid chromatography and mass spectrometry for both discovery and targeted approaches (e.g. TMT PRM label-free DDA & DIA) to support cell surface target discovery.
Use data processing software (e.g. Proteome Discover Spectronaut DIA-NN) and collaborate with the bioinformatics team for streamlined data sharing.
Work closely with scientists across functions present analysis results to stakeholders collaborate on data integration and utilize external resources as needed.
Present research findings to colleagues at scientific meetings (oral or poster presentations) and publish in peer-reviewed journals.
Maintain detailed records of experiments protocols and analyses.
Additional Qualifications/Responsibilities
What we expect of you
We are all different yet we all use our unique contributions to serve patients. The vital attribute professional we seek is a type of person with these qualifications.
Basic Qualifications:
Doctorate degree or
Masters degree and 3 years of scientific experience or
Bachelors degree and 5 years of scientific experience
Preferred Qualifications:
A technical understanding of mass spectrometry and data analysis for quantitative proteomic research including DDA DIA TMT PTM analysis with an emphasis on proximity labeling and cell surface proteomics.
Demonstrated capability of troubleshooting and evaluating LC/MS performance.
A proven track record of scientific innovation and accomplishment in mass spectrometry and proteomics as demonstrated by a strong publication record and conference presentations.
Experience in cell surface proteomic approaches including enrichment methods such as cell surface capture and photo catalytic proximity labeling.
Function optimally in a team-based or collaborative environment as part of a highly integrated team possess excellent organizational verbal and written communication skills and demonstrate the ability to produce reliable and reproducible results.
Experience with automated sample handlers (e.g. Opentrons Agilent Bravo AssayMAP Kingfisher) or other high-throughput approaches.
Demonstrated capability of working with diverse sample types including cell lines tissues (mass-limited) biofluids and FFPE.
What you can expect from us
As we work to develop treatments that take care of others we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture well support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills experience and qualifications.
In addition to the base salary Amgen offers a Total Rewards Plan based on eligibility comprising of health and welfare plans for staff and eligible dependents financial plans with opportunities to save towards retirement or other goals work/life balance and career development opportunities that may include:
A comprehensive employee benefits package including a Retirement and Savings Plan with generous company contributions group medical dental and vision coverage life and disability insurance and flexible spending accounts
A discretionary annual bonus program or for field sales representatives a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models including remote and hybrid work arrangements where possible
Salary Range
149722.00 USD - 177113.00 USD
Required Experience:
Senior IC
Employment Type
Full Time
