Senior Principal Research Scientist, Physics-Based Methods Development
Senior Principal Research Scientist, Physics-Based Methods Development
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Job Description
Job Description
We are seeking a highly motivated and experienced Computational Chemist to join our Data and Computational Sciences Group in Boston to lead scientific innovation in physicsbased molecular modeling and simulations. As a recognized expert and thought leader you will develop the companys physicsbased computational methods platform: prototype benchmark and implement computational methodologies collaborate with software engineers to scale solutions across with organization collaborate with other scientists to establish best practices and drive global alignment to accelerate drug discovery. This is a highly visible scientifically influential role with broad impact across multiple therapeutic areas.
This is a Boston based hybrid position requiring 3 days/week onsite.
Key Responsibilities:
- Develop implement and optimize advanced physicsbased methods including:
- Alchemical and endpoint free energy methods (e.g. FEP MM/GBSA) for potency selectivity and optimization.
- Highperformance molecular dynamics (MD) and enhanced sampling (e.g. metadynamics REST) to explore conformational landscapes and transitions.
- Refinement of artificial intelligence derived protein structures to resolve ambiguous or flexible regions and preparation of active siteready structures for reliable docking.
- Virtual screening workflows using physicsbased docking and scoring.
- Model complex drug modalities beyond Ro5 such as peptides with conformational constraints and challenging permeability profiles.
- Collaborate with ML/AI scientists and computational chemists to evaluate and implement ML enabled physicsbased methods
- Serve as a technical and scientific SME influencing both strategic direction and daytoday execution.
- Work with scientific engineers to ensure highperformance physicsbased platforms are robust and accessible from cloud and onprem compute resources.
- Proactively seek opportunities to enhance Vertexs global R&D efforts through crossfunctional collaboration with Structural Biology and Data Science teams
- Stay at the forefront of computational chemistry innovations proactively incorporating emerging tools and technologies to enhance team capabilities
- Mentor and guide junior scientists fostering a culture of innovation collaboration and scientific excellence
Skills and qualifications required:
- Ph.D. in Computational Chemistry Biophysics Chemical Physics or related field with 6 years of postPh.D. experience in biotech pharma or academic research or Masters and 9 years or Bachelors and 11 years
- Expertise in free energy methods molecular simulations and computational drug design.
- Demonstrated experience in developing methods with successful impact in translating to realworld drug discovery. Deep understanding of proteinligand interactions and membrane systems.
- Fluency with simulation packages (e.g. AMBER GROMACS) and familiarity with common toolkits such as OpenMM OpenFF
- Strong software development skills in Python and C/C and scripting (Python Bash etc.) and familiarity with modern software development practices
- Excellent leadership communication and decisionmaking skills fostering collaboration across teams
#LISV1
#LIHybrid
Pay Range:
$0 $0Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors including skills competencies experience and other jobrelated factors permitted by law.
At Vertex our Total Rewards offerings also include inclusive marketleading benefits to meet our employees wherever they are in their career financial family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical dental and vision benefits to generous paid time off (including a weeklong company shutdown in the Summer and the Winter) educational assistance programs including student loan repayment a generous commuting subsidy matching charitable donations 401(k) and so much more.
Flex Designation:
HybridEligible Or OnSite EligibleFlex Eligibility Status:
In this HybridEligible role you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. OnSite: work five days per week onsite with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and nondiscrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an EVerify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at
Required Experience:
Staff IC
Employment Type
Full-Time
