Post Doctoral Researcher in Molecular Mechanisms of Genetic Kidney Disorders
Post Doctoral Researcher in Molecular Mechanisms of Genetic Kidney Disorders
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Job Description
Union: NonUnion
Site: Toronto General Hospital Research Institute
Department: Advanced Diagnostics
Reports to: Dr. Barua Moumita Principal Investigator
Work Model: Onsite
Hours: 37.5 hours per week
Shifts: Day
Status: Temporary Fulltime
Closing Date: 30 June 2025
The Barua lab is seeking an enthusiastic highly motivated organized individual with exceptional interpersonal skills for a twoyear potentially extendable fulltime postdoctoral position. The laboratory of Dr. Moumita Barua investigates molecular mechanisms underlying genetic kidney disorders including Alport syndrome congenital abnormalities of the kidney and urinary tract and Joubert syndrome. The laboratory is located in the vibrant research environment within the MaRS Discovery District attached to Toronto General Hospital and is supported by peer reviewed (CIHR Kidney Foundation of Canada) and philanthropic grants.
Dr. Moumita Barua is a clinician scientist at University Health Network Senior Scientist at Toronto General Research Institute and an Associate Professor of Medicine at the University of Toronto. Her mission is to improve diagnostics and clinical outcomes in patients with kidney diseases.
The starting point of the Barua research program is to perform genetic studies in adults with kidney disease using patient and population based cohorts. The human genetic discoveries prioritize clinically relevant models to study kidney disease mechanisms in the lab. The overall objective is to advance preclinical development of novel molecular targets and therapeutics. The 3 main projects in the lab are:
1. Genomewide association studies of kidney traits
2. Pax2 mediates kidney repair/regeneration enthusiasm to work with mouse models is an asset
3. Mechanisms in Alport syndrome enthusiasm to work with mouse models is again an asset
Duties
- Design and execute molecular experiments involving nextgeneration and singlecell sequencing.
- Analyze and interpret largescale multiomics data including epigenomics transcriptomics and proteomics.
- Conduct preclinical studies using mouse models of kidney disease.
- Collaborate with laboratory scientists to integrate and validate findings.
- Prepare manuscripts reports and presentations for internal and external audiences.
- Contribute to grant applications and progress reports.
Qualifications :
- PhD (or equivalent) in a relevant field such as molecular biology bioinformatics genomics or biomedical sciences.
- Demonstrated experience working with large data sets including statistical analysis and interpretation.
- Proficiency in analyzing nextgeneration sequencing (NGS) data including wholegenome exome RNAseq and singlecell sequencing.
- Handson experience with singlecell sequencing techniques and associated data analysis tools.
- Experience using or generating proteomics data including mass spectrometrybased approaches.
- Solid understanding of kidney disease biology or demonstrated interest in renal pathophysiology.
- Familiarity with mouse models including handling genotyping and phenotypic characterization.
- Experience working in collaborative interdisciplinary research environments.
- Background in systems biology or networkbased approaches to disease modeling.
- Prior work involving translational research or preclinical models of kidney disease
Additional Information :
Why join UHN
In addition to working alongside some of the most talented and inspiring healthcare professionals in the world UHN offers a wide range of benefits programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor allowing you to find value where it matters most to you now and throughout your career at UHN.
- Competitive offer packages
- Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP access to Transit and UHN shuttle service
- A flexible work environment
- Opportunities for development and promotions within a large organization
- Additional perks (multiple corporate discounts including: travel restaurants parking phone plans auto insurance discounts onsite gyms etc.)
Current UHN employees must have successfully completed their probationary period have a good employee record along with satisfactory attendance in accordance with UHNs attendance management program to be eligible for consideration.
All applications must be submitted before the posting close date.
UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.
Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading inaccurate or incorrect UHN reserves the right to discontinue with the consideration of their application.
UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.
We thank all applicants for their interest however only those selected for further consideration will be contacted.
Remote Work :
No
Employment Type :
Fulltime
Employment Type
Full-time
