Research Fellow (ALS) - Center for Genomic Medicine - Stanton Lab
Research Fellow (ALS) - Center for Genomic Medicine - Stanton Lab
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Job Description
Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a notforprofit we support patient care research teaching and community service striving to provide exceptional care. We believe that highperforming teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
For specific inquiries please email with the subject header Research Position Inquiry: Research Fellow in Functional Genomics. Applicants should send a cover letter CV and contact information for three professional references. Accompanying letters of recommendation are encouraged but not strictly required.The Stanton Lab in the Center for Genomics Medicine (CGM) and Department of Neurology at Harvard Medical School and Massachusetts General Hospital is seeking a highly motivated and skilled scientist to be the driver of our effort to leverage advanced bioengineered organoid models for gaining new insights into mechanisms underlying ALS translatable to effective preventative and therapeutic interventions. The scientist will build on and further develop close collaborations with worldleading experts in ALS and genetics within the Department of Neurology and CGM and technology of the Stanton Lab ().
Core areas of focus will include translating genetics and human biology observations from patient samples to effective preclinical in vitro models and in vivo mouse models to understand multicellular mechanisms in ALS modeling functional consequences of therapeutic interventions and performing and leveraging multiomics analyses to identify enhanced therapeutics approaches. The candidate will join a multidisciplinary and highly collaborative research environment that includes neuroscientists geneticists bioengineers computational biologists and physicianscientists at the CGM and Department of Neurology as well as at other leading academic institutions and biopharmaceutical companies.
Qualifications
Ph.D. in Neuroscience Biology Immunology Bioengineering or related field with deep expertise in molecular and cellular biology techniques
Strong research experience in neurodegenerative disease biology (preferred)
Strong research experience in human iPSC technology and targeted genome editing in vitro (preferred)
Strong research experience in microglia/macrophage biology (preferred)
Knowledge of experimental design
Statistical and quantitative analysis skills
Basic bioinformatics skills (preferred)
Selfmotivated and highly dedicated
Effective organizational and prioritization skills
Effective oral written and interpersonal communication skills
Ability to work both independently as well as collaboratively in a multidisciplinary environment
Strong research experience in highthroughput technologies (e.g. NGS and CyTOF) for bulk and singlecell transcriptomics epigenomics lipidomics and/or proteomics (preferred)
orStrong research experience in functional genomics (e.g. siRNA shRNA CRISPR/Cas9 and chemogenomic) screens (preferred)
orStrong research experience in biomaterials or 3D organoid systems (preferred)
orStrong research experience in mouse microglia/macrophage biologyin vivo(preferred)
For specific inquiries please email with the subject header Research Position Inquiry: Research Fellow in Functional Genomics. Applicants should send a cover letter CV and contact information for three professional references. Accompanying letters of recommendation are encouraged but not strictly required.
Additional Job Details (if applicable)
Remote Type
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Scheduled Weekly Hours
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EEO Statement:
Mass General Brigham Competency Framework
At Mass General Brigham our competency framework defines what effective leadership looks like by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half PeopleFocused half PerformanceFocused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance make hiring decisions identify development needs mobilize employees across our system and establish a strong talent pipeline.
Employment Type
Grant
