Senior Research Investigator/Scientific Leader (Biologics), London or Lausanne

Senior Research Investigator/Scientific Leader (Biologics) London or Lausanne

We are here to advance human health by reimagining drug discovery with the power and pace of artificial intelligence.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured by better and faster drug discovery.

Our values exist in service of that future. We think theyll help us bring it closer too.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one were building today. It starts with the culture at this company. It starts with you.

About Iso

Isomorphic Labs (IsoLabs) was founded in 2021 and is led by Sir Demis Hassabis. Our aim is to usher in a new era of biomedical breakthroughs and find cures for some of humanitys devastating diseases.

Our foundations are built on the success of Google DeepMinds AlphaFold but we didnt stop there! We are continuing to develop and implement stateoftheart technologies as we move towards our goal of dramatically accelerating and improving the process of designing and bringing new medicines to patients.

We have built a worldleading drug design engine comprising foundational AI models that are capable of working across multiple therapeutic areas and drug modalities. The company is continually innovating on model architecture and developing cuttingedge capabilities to advance rational drug design.

Your impact

Are you an experienced antibody and protein engineering expert ready to redefine therapeutic discovery

Isomorphic Labs is seeking a Senior Research Investigator/Scientific Leader to spearhead the design of novel large molecule therapeutics by harnessing the transformative power of our cuttingedge generative AI platform.

This is an exciting opportunity to work closely with Isomorphic labs world leading AI ML and drug discovery experts to develop imaginative new ways based on generative AI to design and optimize protein based therapeutics. You will play a pivotal role in our biologics drug design projects working with key internal and external stakeholders to progress exciting projects in early Drug Discovery through to Candidate Selection and ultimately towards clinical impact.

This role demands a blend of deep scientific expertise and the intellectual curiosity to explore uncharted territory in therapeutic design.

What you will do

• Embed cuttingedge AI into modern drug design principles and define the scientific and technical direction of antibody therapeutic programs aligned with the company goals.

• Champion the de novo design and engineering of novel biologics from concept to candidate.

• Work seamlessly with multidisciplinary internal teams (ML Biology Chemistry) and external partners to deliver highquality datadriven scientific solutions.

• Oversee external collaborations and lead programs to meet critical milestones and progress efficiently.

• Foster a culture of scientific excellence by mentoring and guiding the development of fellow team members within our growing biologics group.

Skills and qualifications

Essential:

• A PhD in Immunology Molecular Biology Biochemistry or a related scientific discipline.

• Substantial industry experience (pharma/biotech) focused on large molecule drug discovery.

• Proven track record leading or significantly contributing to multidisciplinary teams in the discovery and optimization of antibody therapeutics.

• Deep expertise in antibody lead discovery engineering and optimization strategies including handson experience with complex formats (e.g. multispecifics ADCs).

• Indepth understanding of protein structurefunction relationships and experience applying de novo design or advanced protein engineering principles (eg. affinity maturation liability derisking developability assessment).

• Exceptional communication presentation and interpersonal skills with the ability to articulate complex ideas to diverse audiences.

• Demonstrated success managing external collaborations (industry/CROs) for therapeutic antibody development.

• Strategic mindset with strong problemsolving critical thinking and decisionmaking capabilities.

• An entrepreneurial spirit comfortable thriving in a fastpaced innovative and rapidly evolving environment with a drive to achieve ambitious goals. You possess intellectual curiosity and a willingness to challenge conventional thinking.

Nice to have:

• Project leadership experience across multiple biologics platforms or modalities.

• Experience in immunology and/or oncology therapeutic areas within a biologics discovery context.

• Prior experience leveraging machine learning or computational biology techniques for biologics design and optimization.

Culture and values

We are guided by our shared values. Its not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

Thoughtful
Thoughtful at Iso is about curiosity creativity and care. It is about good people doing good rigorous and futuremaking science every single day.

Brave
Brave at Iso is about fearlessness but its also about initiative and integrity. The scale of the challenge demands nothing less.

Determined
Determined at Iso is the way we pursue our goal. Its a confidence in our hypothesis as well as the urgency and agility needed to deliver on it. Because disease wont wait so neither should we.

Together
Together at Iso is about connection collaboration across fields and catalytic relationships. Its knowing that transformation is a group project and remembering that what were doing will have a real impact on real people everywhere.

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. Were building an environment where collaboration is fundamental learning is shared and every employee feels supported and able to thrive. We value unique experiences knowledge backgrounds and perspectives and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex race religion or belief ethnic or national origin disability age citizenship marital domestic or civil partnership status sexual orientation gender identity pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation please do not hesitate to let us know.

Hybrid working

Its hugely important for us to share knowledge and build strong relationships with each other and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model and would require you to be able to come into the office 3 days a week (currently Tuesday Wednesday and one other day depending on which team youre in). If you have additional needs that would prevent you from following this hybrid approach wed be happy to talk through these if youre selected for an initial screening call.

Please note that when you submit an application your data will be processed in line with our .

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