Director Protein Engineering & Novel Modalities
Director Protein Engineering & Novel Modalities
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$ 172672 - 259008
1 Vacancy
Job Description
We are seeking a talented and highly influential leader to effectively direct and manage a multidisciplinary team of highly experienced scientists to advance bispecific antibody technologies and deliver bispecific programs into the pipeline.
In this role you will collaborate with project leaders across all therapeutic areas to understand the target biology and to directly steer and influence discussions and decisions related to the development of an appropriate drug modality. As a recognized leader with a proven publication track record in the field of protein engineering and antibody drug development you will expand existing bispecific platform technologies and drive scientific innovation contributing to AstraZeneca pipeline progression. While working productively and proficiently in a highly dynamic scientifically rigorous and fastpaced environment you will effectively represent the department in crossfunctional meetings governance committees and due diligences.
Summary of the Group
Biologics Engineering (BE) is responsible for the discovery and optimization of next generation biologics to create biological drug candidates for all key therapeutic areas such as oncology respiratory and inflammation cardiovascular renal metabolic and infectious diseases. Were constantly pushing the boundaries of science to deliver lifechanging medicines to patients with a passion for the development of inhouse biologics discovery platforms and novel drug modalities to address unmet medical needs.
Position Requirements & Responsibilities:
- Lead and expand a team of scientists to advance innovative bispecific technologies and support bispecific pipeline progression.
- Collaborate and work closely with scientific leads across all therapeutic areas to ensure timely progress of pipeline projects and drive technological innovations.
- Direct and progress bispecific programs from early discovery to development stage.
- Establish highlevel of scientific innovation and develop bispecific technologies for enhanced selectivity improved developability and reduced offtarget and offorgan toxicities to ensure scientific excellence and effective achievement of research goals.
- Track record of scientific innovation as evidenced by strong scientific publications inventorship on patents and presentations at major conferences.
Education/Experience Requirements:
Ph.D in Biotechnology Biochemistry Molecular Biology or other relevant scientific field with 10 years of experience in antibody engineering and/or bispecific antibody technologies in the Biotech or Biopharmaceutical industry
Required Skills:
- Proven record in antibody drug development and driving bispecific programs from early discovery into development stage.
- Proven ability to lead a team setting goals and objectives motivate and develop others and influence recruitment of high performing staff.
- Extensive handson experience in molecular biology antibody design and engineering and characterization of various bispecific antibody formats.
- Demonstrated ability to influence and build strong relationships with internal and external collaborators while working effectively in a collaborative team environment across multiple functions.
- Track record of problem solving risk management negotiating and influencing skills
- Strong industry leadership experience excellent written and verbal communication skills and effective presentation of complex scientific reports to crossfunctional and senior management teams are essential for this role.
Desired Skills:
- Strong background in immunology T cell biology and cancer biology.
- Strong experience in structure/functionbased techniques including crystallography Cryo EM.
- Deep understanding of various imaging/multicolor flow cytometrybased instruments and data analysis programs.
- Experience in antibody discovery using one of several displaybased technologies is preferred but not essential.
- Experience in development of in vivo mouse models and subsequent analysis for efficacy and PK.
The annual base pay for this position ranges from $172672.00 $259008.00. Hourly and salaried nonexempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors including market location jobrelated knowledge skills and experience. In addition our positions offer a shortterm incentive bonus opportunity; eligibility to participate in our equitybased longterm incentive program (salaried roles) to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an atwill position and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factors.
Date Posted
29Apr2025Closing Date
13May2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Director
Employment Type
Full-Time
