Research Associate I
Research Associate I
Posted on :
12-05-2025
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1 Vacancy
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Job Description
General information
Location
Cambridge MA
Ref #
42275
Job Family
Research
Workplace
OnSite
Date published
08May2025
Time Type
Full time
Description & Requirements
The Broad Institute of MIT & Harvard is looking for an outstanding research associate to join the Nehme Lab at the Stanley Center for Psychiatric Research. Based on unprecedented insights into the genetic basis of neurodevelopmental neurodegenerative and psychiatric diseases the Nehme lab aims to uncover key disease mechanisms using human stem cell derived models.
The successful candidate will join a multidisciplinary group and perform cuttingedge research on the molecular cellular and neurobiological mechanisms of psychiatric disorders. Specifically the candidate will generate human brain cell types from human pluripotent stem cells (hPSCs) in vitro in order to investigate causal relationships between diseaseassociated genetic variants and neuronal phenotypes. The candidate will address fundamental scientific questions formulate hypotheses design and execute experiments analyze and interpret data and write and publish original papers often in teamwork with other lab members and external collaborators. We emphasize research training and career development for all lab members. Research activities will take place at the Broad Institute.
CHARACTERISTIC DUTIES
Develop and apply multiple methods to routinely maintain and manipulate different types of cell cultures primary rodent neural culture or human pluripotent stem cells and stem cell derived neurons and astrocytes
Generate diseaserelevant human neurons or astrocytes from hPSCs in vitro
Perform basic molecular biology such as plasmid construction qPCR RNA sequencing library preparation and QC.
Perform basic biochemical manipulations and analysis such as protein lysate preparation western blotting and immunoprecipitations
Assist with related lab management duties
Work closely with multidisciplinary teams to provide technical expertise and develop project specific protocols
Troubleshoot to resolve problems and participate in new technology evaluation development and implementation
Document compile and analyze experimental data
Attend and present at team meetings to share results plan projects and experiments and ensure that projects support team goals
May perform other duties as assigned
QUALIFICATIONS
B.S./B.A. in biology neurobiology chemistry molecular/cellular biology or a related field
Minimum 12 years of industrial or academic experience in mammalian tissue culture
Experience with stem and/or neuronal cell culture preferred
Prior molecular cellular and biochemical experience preferred
Experience in computational/bioinformatics approaches to biological problems preferred
Outstanding personal initiative and communication skills
Must be able to work independently and on multidisciplinary project teams
Exceptional organizational and time management skills lab notebook practices and attention to detail
Must be willing and able to develop and shift plans in service of a rapidly changing environment and troubleshoot to solve problems
Required Experience:
IC
Employment Type
Full Time
Key Skills
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