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The Position

A healthier future is what drives us to innovate to continuously advance science and to ensure everyone has access to the healthcare they need today and for generations to come.

As a Principal Quantitative Scientist you are responsible for leading conceptualizing planning and executing advanced realworld data (RWD) projects to generate evidence in support of the CDS portfolio clinical tests diagnostic devices and services developed and marketed by Roche Diagnostics leading to better and more efficient patient care. You will contribute to broad product support initiatives and/or studies lead and deliver on complex projects and interact with external partners without supervision.

The data you will be working with are varied in type including but not limited to clinical patientlevel data supplemented with data such as omics imaging digital health etc. You will lead and collaborate with peers within the function and across the organization to develop and improve existing strategies CDS and workflow solutions improve product support strategies identify evidence gaps and data sources design and execute studies implement analyses to support improvement of existing products and lead discovery and early development of new features or apps to drive the NAVIFY portfolio as well as Diagnostics clinical tests devices and services. You will be able to quantify the value of these products from both a patient outcome and business value as well as from a regulatory perspective. You will drive the creation of best practices and share learnings/experience with colleagues both internal and external to the function to shape the use of RWD and implement sustainable sciencebased practices in Diagnostics.

The Opportunity:

In this position you will also ensure that the design execution and presentation of evidence adhere to the highest scientific standards. To succeed you will leverage your expertise and expand your knowledge of available healthcare data sources and applicable stateoftheart methodologies. Handson experience with largescale processing and visualization of RWD through various languages and tools (e.g. R Python (no)SQL Spark etc.) is required. In addition you will rely on your scientific expertise and your ability to interact and influence crossfunctional experts such as clinical biostatisticians data scientists and product owners to discover novel insights demonstrating the impact of various treatment decisions and uncover key elements leading to the best outcomes for patients.

This role is hybrid with a physical presence at one of the following Roche campuses: Indianapolis USA.

Responsibilities include:

• Provide RWD leadership for evidence generation using RWD supporting InVitro Diagnostics (IVD) and CDS product portfolio at Roche Diagnostics.

• Drive the primary strategic and operational responsibility for the design execution and reporting of RWD studies using a variety of available research and commercial healthcare databases.

• Identify and establish collaborations with healthcare institutes expanding sources of available RWD sources.

• Work closely with product leads clinical development clinical operations and medical affairs directors across Roche Diagnostics to create confirm and validate disease & clinical hypotheses for RWD projects supporting commercial market access medical and regulatory needs.

• Promote the increased adoption and use of RWD to supplement clinical study design and execution and identify opportunities where RWD could be the primary evidence generation mechanism to achieve regulatory and reimbursement objectives for IVD and CDS products being developed across Roche Diagnostics.

• Develop RWD study protocols and lead analysis projects supporting evidence needs of IVD and CDS product portfolio. Collaborate with internal and external partners (e.g. key opinion leaders academic institutions CROs) on the design and implementation of RWD studies.

• Lead RWD analysis projects from start to completion.

• Ensure high quality results from studies are published as posters abstracts and manuscripts at a variety of external and internal events and congresses increasing scientific profile and visibility of the organization.

• Explain the strengths and limitations of RWD such as national/regional registries EMRs and other clinical data sources in the context of designing RWD study designs.

• Mentor more junior colleagues and act as an influential subject matter expert to your team members and the businesses you support.

• Stay committed to offering innovation finding opportunities to enhance ways of working (including processes methods technology etc.) and sharing learnings proactively with peers.

• Use and continue to foster strong working relationships with global colleagues and customers and build a strong network in order to jointly explore vendor relationships data assets analytical methodologies and toolsets.

• Partner with external key opinions leaders institutions academics etc.

Who You Are

• You hold a PhD (preferred) OR Masters Degree in a Quantitative science related field (e.g. Pharmacoepidemiology Epidemiology RWD Biostatistics Pharmacoeconomics Health Economic and Outcomes Research)

• And 7 years of direct related (industry consulting or other relevant) experience required .

• Solid expertise in epidemiology and causal inference methodologies is required.

• Strong programming experience with R Python and/or other quantitative software.

• Strong experience in using research and commercial RWD sources national and regional disease data registries.

Additional Skills:

• Proven handson experience in generating new hypotheses extracting/managing big data sets design implementation and reporting of RWD studies in the Diagnostics/Pharma industry.

• Understanding of regulatory guidelines for Diagnostics/Pharma.

• Expertise in national and international coverage policies and proven experience in the use of RWD to influence reimbursement and clinical guidelines.

• Excellent communication and collaboration skills (including interpersonal skills to contribute effectively in crossfunctional team settings ability to influence others without authority ability to build strong collaborative relationships with scientific and nonscientific partners).

• Strong project management skills (including ability to manage scope and effectively delegate to other functions staff contractors and external vendors).

• Strategic mindset and cando attitude.

• Professional working proficiency in English is required.

• An expert in RWD study design and with handson experience in epidemiology and a passion to make a difference in healthcare.

• A data savvy creative thinker and problem solver eager to learn new techniques and expand your scientific expertise.

• A reliable team player and strong collaborator with influential skills and the ability to become established as a thought partner/leader.

• A resilient problem solver with a sense of ownership effective prioritization skills and attention to detail.

• A recognized team leader with experience in mentoring team members.

You are local to Indianapolis IN

*Relocation benefits are not available for this position.

The expected salary range for this position based on the primary location of Indianapolis IN is between $124500 and $231100. Actual pay will be determined based on experience qualifications geographic location and other jobrelated factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Who we are

A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver lifechanging healthcare solutions that make a global impact.

Lets build a healthier future together.

Roche is an equal opportunity employer. It is our policy and practice to employ promote and otherwise treat any and all employees and applicants on the basis of merit qualifications and competence. The companys policy prohibits unlawful discrimination including but not limited to discrimination on the basis of Protected Veteran status individuals with disabilities status and consistent with all federal state or local laws.

If you have a disability and need an accommodation in relation to the online application process please contact us by completing this form Accommodations for Applicants.