Senior Research Scientist, Structural Biology & Biophysics
Senior Research Scientist, Structural Biology & Biophysics
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
Job Description
Job Description
General Summary:
The Structural Biology and Biophysics group at Vertex Pharmaceuticals is responsible for generating reagents as well as biophysical and structural information that is critical for the advancement of research programs to create transformative medicines for patients with serious diseases. The group is seeking a highly motivated and collaborative Senior Research Scientist with significant experience utilizing biophysical methods for drug design to guide these efforts. The ideal candidate for this labbased role will possess excellent technical skills in sample handling for biophysical studies of small molecule ligand binding and experience with protein science a proven track record in drug discovery strong communication skills and the ability to collaborate with members of an interdisciplinary project team.
Key Duties and Responsibilities:
- Work within drug discovery project teams to design and execute biophysical experiments that answer key questions that aid in molecular design
- Develop execute and interpret ligand binding studies using primarily Surface Plasmon Resonance (SPR) and potentially other orthogonal biophysical methods.
- Design and generation of reagents for biophysical studies
- Sample preparation execution of experiments and organized reporting of results
- Keep up to date with the scientific literature in the field and beyond
- Actively participate in group and crossdisciplinary project team meetings
- Present results to project teams in a clear and understandable way
Knowledge and Skills:
- Experience working with integrated drug discovery teams utilizing structurebased drug design
- Experience in SPR plus additional biophysical techniques such as: Nuclear Magnetic Resonance (NMR) Thermal Shift Analysis (TSA) Spectral Shift/Temperature Related Intensity Change (TRIC) Microscale Thermophoresis (MST) and Isothermal Titration Calorimetry (ITC)
- Understanding and applying biophysical and structural methods to drug discovery
- Ability to develop and execute biophysical assays to measure ligand binding
- Track record of productivity as evidenced by a strong publication record
- Selfmotivation organization and ability to communicate effectively with project teams
Education and Experience:
- Ph.D. (or equivalent degree) in biological science and 25 years of relevant postdoctoral employment experience or
- Masters Degree (or equivalent degree) in biological science and 5 years of relevant employment experience or
- Bachelors Degree (or equivalent degree) in biological science and 8 years of relevant employment experience
Pay Range:
$116000 $174000Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors including skills competencies experience and other jobrelated factors permitted by law.
At Vertex our Total Rewards offerings also include inclusive marketleading benefits to meet our employees wherever they are in their career financial family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical dental and vision benefits to generous paid time off (including a weeklong company shutdown in the Summer and the Winter) educational assistance programs including student loan repayment a generous commuting subsidy matching charitable donations 401(k) and so much more.
Flex Designation:
OnSite DesignatedFlex Eligibility Status:
In this OnSite designated role you will work five days per week onsite with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and nondiscrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an EVerify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at
Required Experience:
Senior IC
Employment Type
Full-Time
