Senior Manager, Clinical Pharmacology and Quantitative Pharmacology

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire lifechanging medicines. Inperson working gives us the platform to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Introduction to role

Are you ready to lead the charge in pharmacometrics As a Senior Manager in Clinical Pharmacology and Quantitative Pharmacology (CPQP) you will be at the forefront of PKPD Modeling and Pharmacometrics (PMX). Your task involves developing and implementing Modeling & Simulation (M&S) plans and strategies guiding compounds from earlystage trials to postmarket phases. Collaborate with crossfunctional teams within Alexion R&D including Clinical Pharmacology Translational Medicine and Biostatistics to enhance our PMX capabilities.

Your expertise will drive the continuous improvement of pharmacometrics skills computational infrastructure and strategic M&S methodologies across diverse projects and disease areas. Take charge of projectrelated M&S assignments whether independently or in collaboration with external PMX CROs. Are you ready to make a difference

Accountabilities

• Lead M&S strategies/plans as a project leader in crossfunctional development teams.
• Apply brand new M&S methodologies to inform decisionmaking at crucial achievements.
• Build quantitative systems biology/pharmacology models with internal teams and external QSP service providers.
• Conduct population PK PKPD analyses clinical trial simulations and modelbased analyses.
• Initiate and coordinate outsourced M&S activities.
• Mentor and coach junior M&S scientists and CPQP scientists.
• Enhance Alexions internal M&S capabilities through training and new tool evaluation.
• Prepare population PK/PD reports and regulatory submission documents.

Essential Skills/Experience

• PhD or equivalent experience in quantitative sciences
• 2 years of pharmaceutical industrial and/or postdoctoral experience in the related teams of clinical pharmacology PKPD and QSP
• Excellent handson knowledge in R and/or SAS NONMEM
• Excellent knowledge in Matlab Mathematica or other QSP related software or computing platform
• Under managers guidance to become well versed at analyzing summarizing plotting complex data to identify trends important for drug development
• Track record of applying quantitative system pharmacology methodologies in a drug R&D context
• Track record of publishing M&S work
• Experience from PMX approaches in hematology nephrology neuromuscular ophthalmology bone endocrinology oncology and/or metabolic rare diseases preferred
• Excellent written and verbal communication skills

Desirable Skills/Experience

• Doctoral degree (PhD or Equivalent training by experience) in clinical pharmacology pharmacology/cell biology/immunology or relevant field
• Background in clinical pharmacology or bioengineering is desired

At Alexion you will find a collaborative culture that encourages innovation and a diverse environment where your contributions are valued. You will have the opportunity to be at the forefront of rare disease research and make a meaningful difference in patients lives.

Ready to lead and inspire Apply now and take the first step towards a fulfilling career at Alexion AstraZeneca Rare Disease.

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Date Posted

Closing Date

Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment training compensation promotion and other terms and conditions of employment based on race color religion creed or lackthereof sex sexualorientation age ancestry national origin ethnicity citizenship status marital statuspregnancy (including childbirth breastfeeding or related medical conditions) parental status (including adoption or surrogacy) military status protected veteran status disability medical condition gender identity or expression genetic information mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin aninteractive dialogue with Alexion regarding an accommodation please contact . Alexion participates in EVerify.