Senior Director, Quantitative Pharmacology and Pharmacometrics
Senior Director, Quantitative Pharmacology and Pharmacometrics
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$ 206200 - 324600
1 Vacancy
Job Description
Job Description
Location:
WP or RY
The Quantitative Pharmacology and Pharmacometrics (QP2) department drive modelinformed drug discovery and development (MIDD) to routinely enable efficient drug discovery/development and/or regulatory decisions. The Pharmacometrics group within QP2 brings an experienced leadership team deep modeling expertise and stateoftheart modeling approaches across multiple therapeutic areas and modalities to drive portfolio impact from discovery through lifecycle management. The team is externally visible and continues to be at the leading edge of building innovative state of the art tools. With MIDD as an essential component of decisionmaking at our Company this position offers an opportunity for the Pharmacometrics leader to drive pipeline impact and lead a talented group of pharmacometricians.
This Senior Director is expected to be an experienced pharmacometrician with a strong understanding of the integrated strategic elements of drug discovery and development and the ability to incorporate Modeling and Simulation (M&S) tools in decision making to drive pipeline impact. She/he will take on primary responsibilities for identifying emerging areas of pharmacometrics innovation and leading QP2 efforts to strengthen our pharmacometrics capabilities on a continuous basis. The Senior Director will be accountable for directing a team of pharmacometricians with diverse backgrounds and bringing subject matter expertise related to model informed drug discovery and development for programs.
The Senior Director in Pharmacometrics should provide strategic leadership for pharmacometrics through the following responsibilities:
Guide a team of approximately 510 pharmacometricians to achieve results on major program drivers by identifying and implementing quantitative approaches (for e.g. translational PK/PD models population pharmacokinetic models exposureresponse models quantitative system pharmacology (QSP) and disease progression models clinical trial simulations comparator modeling) that seek to improve cycle time cost/size and number of trials implementation of tools and framework for driving Go/No Go decisions on programs and rapid regulatory approvals
Foster collaboration within QP2 to achieve results remove barriers on portfolio or scientific priorities
Evaluate and maintain appropriate quality systems and IT infrastructure for QP2 to support emerging capabilities
Responsible for prioritysetting performance management hiring and retention talent development/management for direct reports
Identify resource needs and contribute to resource allocation internally and through management of business operations and outsourcing budgets
Provide functional representation on committees task forces or initiatives spanning beyond QP2
Initiate and manage external collaborations to develop new methodologies and lead our external outreach to the scientific pharmacometrics community
Required Experience:
(a Ph.D. or equivalent degree with 12 years of experience where experience means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia
Educational background in pharmacometrics pharmaceutical sciences mathematics statistics/biostatistics computational biology/chemistry chemical/biomedical engineering or a related field
At least 10 years of discovery/drug development/regulatory experience
Deep expertise in pharmacometrics (e.g. population PK and PK/PD analyses modelbased metaanalysis doseresponse and exposureresponse analyses disease modeling trial simulation optimal study designs strategic decision analyses economic modeling) with ability to understand how MIDD can drive portfolio and regulatory decisions
Extensive experience in developing quantitative strategies for impacting pipeline decisions
Good interpersonal and communication skills that ensure teamwork and productive interactions among diverse personalities/areas of expertise
As an Equal Employment Opportunity Employer we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race color age religion sex sexual orientation gender identity national origin protected veteran status disability status or other applicable legally protected a federal contractor we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws visit:
We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences perspectives skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas broad experiences backgrounds and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.
Learn more about your rights including under California Colorado and other US State Acts
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race color age religion sex sexual orientation gender identity national origin protected veteran status disability status or other applicable legally protected a federal contractor we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws visit:
We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences perspectives skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas broad experiences backgrounds and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.
Learn more about your rights including under California Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5 2023 employees in officebased positions in the U.S. will be working a Hybrid work consisting of three total days onsite per week Monday Thursday although the specific days may vary by site or organization with Friday designated as a remoteworking day unless business critical tasks require an onsite Hybrid work model does not apply to and daily inperson attendance is required for fieldbased positions; facilitybased manufacturingbased or researchbased positions where the work to be performed is located at a Company site; positions covered by a collectivebargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.
The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors which may include but not be limited to the primary work location and the chosen candidates relevant skills experience and education.
Expected US salary range:
$206200.00 $324600.00Available benefits include bonus eligibility long term incentive if applicable health care and other insurance benefits (for employee and family) retirement benefits paid holidays vacation and sick days. A summary of benefits is listed here.
San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no preexisting agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.
Employee Status:
RegularRelocation:
Domestic/InternationalVISA Sponsorship:
YesTravel Requirements:
10%Flexible Work Arrangements:
HybridShift:
1st DayValid Driving License:
NoHazardous Material(s):
N/ARequired Skills:
Business Intelligence (BI) Database Design Data Engineering Data Modeling Data Science Data Visualization Machine Learning Software Development Stakeholder Relationship Management Waterfall ModelPreferred Skills:
Job Posting End Date:
05/16/2025*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Required Experience:
Exec
Employment Type
Full-Time
