Senior Scientist Structural Biology (X-ray crystallography, Cryo EM)
Senior Scientist Structural Biology (X-ray crystallography, Cryo EM)
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Job Description
Job Description
Are you ready to embark on an exhilarating career journey that combines innovation collaboration and impactful scientific discovery At our Company a global leader in pharmaceuticals renowned for our commitment to excellence and groundbreaking research we are committed to improving lives through innovative medicines vaccines and animal health products.
Protein and Structural Chemistry (PSC) a global team in Discovery Chemistry (DC) supports protein structuraldetermination from Discovery to Development agnostic to the modalities (small molecule peptide and macromolecules). Furthermore we elucidate the structural basis of mechanisms of action and perform analysesto develop formulations. PSC is a diverse and inclusive team of approximately 40 structural biologists that collaborate closely with medicinal and computational chemists informaticians mass spectrometrists biophysicists protein scientists and pharmacologists who employ stateoftheart capabilities to drive drug design and development.
We are seeking a creative selfmotivated structural biologist with exceptional interpersonal and problemsolving skills to join our growing PSC group in the DC department at our Boston Massachusetts site. The successful candidate must have experience in Xray crystallography and/or CryoEM and will be responsible for all aspects of the experimental workflow from sample preparation and data collection through data processing structure determination and the effective communication of structural analyses with key stakeholders. Additionally the candidate will work proactively with colleagues in Modeling & Informatics Discovery Chemistry Screening and Compound Profiling and Mass Spectrometry and Biophysics and will also be expected to identify and manage internal and external scientific partnerships as necessary.
Productive and collaborative interactions with other members of our global crossfunctional department are in this role. Inclusive and collaborative use of internal expertise and resources will be essential to success. The successful candidate is expected to foster and contribute to a diverse workforce where colleagues and partners feel comfortable bringing their unique perspectives to work.
The position requires active interaction with the external scientific community to continually improve scientific understanding including presentations at external meetings.
There is an expectation for periodic travel to other locations.
Required Experience and Skills:
Ph.D. in structural biology biochemistry or related field.
Experience in a broad range of activities for Xray crystallography including crystallization screening and optimization crystal harvesting data collection and structure determination and/or proficiency in atomic resolution single particle CryoEM including sample preparation data collection image processing and structure determination.
Excellent written and verbal communication skills to facilitate team progress and ensure clarity on program status for therapeutic team and management is .
Demonstrated strong organizational abilities with a proven track record of managing timeline effectively.
Ability to prepare and publish peerreviewed research.
Preferred Experience and Skills:
Experience with structure determination of small moleculeprotein complexes and multisubunit protein complexes.
Knowledge of current biophysical and functional characterization methods (e.g. SPR thermal shift ligandbinding and calorimetric assays) to inform construct design and optimization.
Experience using computational tools for protein engineering and design.
Experience with scientific programming (e.g. Python) and interest in the application of computational tools to answer structural biology questions.
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U.S. Hybrid Work Model
Effective September 5 2023 employees in officebased positions in the U.S. will be working a Hybrid work consisting of three total days onsite per week Monday Thursday although the specific days may vary by site or organization with Friday designated as a remoteworking day unless business critical tasks require an onsite Hybrid work model does not apply to and daily inperson attendance is required for fieldbased positions; facilitybased manufacturingbased or researchbased positions where the work to be performed is located at a Company site; positions covered by a collectivebargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.
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Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no preexisting agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.
Employee Status:
RegularRelocation:
Domestic/InternationalVISA Sponsorship:
YesTravel Requirements:
10%Flexible Work Arrangements:
Not ApplicableShift:
Not IndicatedValid Driving License:
NoHazardous Material(s):
N/AJob Posting End Date:
05/13/2025*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Required Experience:
Senior IC
Employment Type
Full-Time
