Principal Scientist, High Throughput Production Group Leader, Discovery Biologics
Principal Scientist, High Throughput Production Group Leader, Discovery Biologics
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Job Description
Job Description
We are on a quest for cures and are committed to be the worlds premier most researchintensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and worldclass R&D with the purpose of turning breakthrough science into lifechanging medicines.
We are seeking an exceptional and experienced scientist in the role of Principal Scientist in the Boston Discovery Biologics group. The qualified candidate will be a scientist with core capabilities in high throughput approaches to construct design molecular biology expression and purification methods for biologics. They should have a deep expertise in the design execution and optimization of high throughput production methodology supporting reagent and therapeutic screening efforts of diverse therapeutic modalities. They will work closely with protein engineering and science teams across Discovery Biotherapeutics in addition to the Biologics Production and Engineering team in Boston to ensure the execution of fitforpurpose production approaches. They may serve as a functional area representative for protein engineering and production on project teams driving protein therapeutic programs from concept through hit identification and lead optimization. The ideal candidate will leverage handon experience developing and executing workflows on multiple common automated liquid handing platforms such as Tecan Hamilton and Lynx to deliver therapeutic candidates supporting programs from screening through lead optimization. Our organization is directly integrating computational and wetlab researchers with stateoftheart automation to accelerate the discovery engineering and characterization of novel biologics in the preIND pipeline.
As a people manager they will invest in the growth and development of current and future staff to create a culture of collaboration and accountability to enable shared success. They will work closely with their team members to leverage strengths and identify opportunities to continually expand technical skillsets and enterprise thinking. They will work to support the departments efforts to recruit diverse and highly skilled key talent to the organization and be a champion for diversity and inclusion. We recognize that the diversity in our team is our strength and we are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of researchers to drive our core mission.
What you will do:
Leverage deep high throughput production expertise to deliver diverse biologics modalities
Work with program leaders protein engineers and molecular biologists to develop and implement biologic screening campaign strategies
Perform and oversee high throughput production workflows enabling the critical experiments for pipeline programs through preclinical candidate selection.
Develop and implement supporting downstream workflows including hit picking concentration normalization and formulation for project teams within and beyond Discovery Biologics
Serve as the protein production representative on project teams driving protein therapeutics programs from concept through hit identification and lead optimization with discovery program leadership opportunities
Mentor 2 direct reports and team members in supporting discovery programs from design through production of multiple biologics modalities
Train and develop junior scientists
Effectively partner across multidisciplinary interfaces to achieve organizational objectives.
Stay abreast of external advancements in the relevant scientific fields
Promote the external reputation of our companys Discovery Biologics
What you will need to be successful in this role:
Qualifications & Experience
Ph.D. in biology biochemistry structural biology or related field with 8 years relevant industry experience Masters with 12 years relevant industry experience or Bachelors with 14 years of relevant industry experience in biochemistry or related field
Experience in advancing protein therapeutics through discovery toward candidate selection
Excellent communication and collaboration skills
Strong presentation and publication record
Required skills:
Strong technical knowledge of multiple aspects of high throughput screening workflows including design expression purification and characterization of biologics
Handson experience establishing and running high throughput automated workflows
Prior direct experience as a protein production lead on protein therapeutics discovery project teams from toolmolecule generation through preclinical development of therapeutic candidates
Group leadership experience of with a demonstrated passion for and a track record of talent development
Established external reputation through highimpact publications presentations and/or scientific community engagement
Preferred skills:
Ideal candidate will have handson experience with multiple production scales and varied liquid handing platforms
Previous high throughput production group leadership is highly desirable
Experience successfully maintaining a robust discovery production pipeline
Discovery project leadership experience a strong plus
Programming skills enabling protocol authoring automated data capture/reporting and data visualizations would be beneficial
Experience in outsourcing and managing external collaborations
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We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences perspectives skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas broad experiences backgrounds and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.
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As an Equal Employment Opportunity Employer we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race color age religion sex sexual orientation gender identity national origin protected veteran status disability status or other applicable legally protected a federal contractor we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws visit:
We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences perspectives skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas broad experiences backgrounds and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.
Learn more about your rights including under California Colorado and other US State Acts
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Effective September 5 2023 employees in officebased positions in the U.S. will be working a Hybrid work consisting of three total days onsite per week Monday Thursday although the specific days may vary by site or organization with Friday designated as a remoteworking day unless business critical tasks require an onsite Hybrid work model does not apply to and daily inperson attendance is required for fieldbased positions; facilitybased manufacturingbased or researchbased positions where the work to be performed is located at a Company site; positions covered by a collectivebargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.
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Employee Status:
RegularRelocation:
DomesticVISA Sponsorship:
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No Travel RequiredFlexible Work Arrangements:
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05/4/2025*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Required Experience:
Staff IC
Employment Type
Full-Time
