Principal Scientist Anatomic Pathologist
Principal Scientist Anatomic Pathologist
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Job Description
Job Description
Job Description:
Translational Molecular Biomarkers is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our companys Research Laboratories. Translational Molecular Biomarkers laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms of drug action and patient response.
The Molecular Pathology group within the Translational Molecular Biomarkers organization is seeking a highly motivated and experienced Anatomic Pathologist (MD) for the role of Principal Scientist to join our innovative team. This position will play a crucial role in the supporting the development analytical validation and testing of histopathologybased assays for clinical implementation and advancing digital pathology within our companys clinical therapeutic pipeline.
The individual will have the following responsibilities:
Engage in providing thorough histopathological reviews and testing clinical samples leveraging expertise in disease processes and pathways targeted by our companys therapeutics.
Collaborate in the development and analytic validation of digital pathology algorithms.
Interface with scientists and physicians in early and latestage clinical development to execute histopathologybased biomarker strategies in clinical trials.
Establish new histopathologybased assays in the laboratory as part of a team.
Provide subject matter of expert pathologist input to discussions in a highly matrixed environment collaborating with internal and external stakeholders.
Position Qualifications:
Education Minimum Requirement:
Doctor of Medicine (MD or MD/PhD) with specialized training in Anatomic Pathology.
Required Experience and Skills:
Proficient in routine histopathology testing immunohistochemistry (IHC) cytogenetics (insitu hybridization) testing procedures and applicable laboratory testing regulations.
Experience ensuring compliance of a clinical laboratory with regulatory standards.
Experience with the development and analytic validation of digital pathology algorithms.
Excellent oral and written skills with a proven record of scientific contributions to the scientific community.
Demonstrated ability to lead and manage projects in a fastpaced environment.
Ability to interact well with diverse groups and maintain strong working relationships with internal and external collaborators.
Eplinary teams.
Strong understanding of disease processes and pathways relevant to our companys therapeutics.
Preferred Experience and Skills:
Experience working in the pharmaceutical industry.
Broad knowledge of the drug development process and translational medicine.
Experience in clinical biomarker development or managing the implementation of biomarker assays in support of drug development.
Experience with multiplex tissuebased spatial profiling assays (i.e. multiplex immunofluorescence multiplex chromogenic immunohistochemistry imaging mass cytometry).
Familiarity with image acquisition platforms (i.e. Leica Aperio Hamamatsu Pannoramic).
Proficiency in commercial or opensource image analysis software packages (i.e. Visiopharm HALO QuPath).
Knowledge of using statistical software packages (i.e. Prism SPSS).
Understanding of regulated clinical bioanalysis.
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As an Equal Employment Opportunity Employer we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race color age religion sex sexual orientation gender identity national origin protected veteran status disability status or other applicable legally protected a federal contractor we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws visit:
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U.S. Hybrid Work Model
Effective September 5 2023 employees in officebased positions in the U.S. will be working a Hybrid work consisting of three total days onsite per week Monday Thursday although the specific days may vary by site or organization with Friday designated as a remoteworking day unless business critical tasks require an onsite Hybrid work model does not apply to and daily inperson attendance is required for fieldbased positions; facilitybased manufacturingbased or researchbased positions where the work to be performed is located at a Company site; positions covered by a collectivebargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.
San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance
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Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no preexisting agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.
Employee Status:
RegularRelocation:
DomesticVISA Sponsorship:
NoTravel Requirements:
No Travel RequiredFlexible Work Arrangements:
HybridShift:
Not IndicatedValid Driving License:
NoHazardous Material(s):
N/AJob Posting End Date:
05/2/2025*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Required Experience:
Staff IC
Employment Type
Full-Time
