Associate Director Production Process Improvement

Broad Institute

Posted on : 30-04-2025

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1 Vacancy

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Job Location

Burlington - USA

Monthly Salary

Not Disclosed

Salary Not Disclosed

Vacancy

1 Vacancy

Posted on : 30-04-2025

Job Description

General information

Location

Burlington MA

Ref #

42194

Job Family

Research

Workplace

Hybrid

Date published

28Apr2025

Time Type

Full time

Description & Requirements

Broad Clinical Labs at the Broad Institute of MIT & Harvard are seeking a highly motivated and technically exceptional individual to work in the change management team. The role will involve close coordination with BCLs operational regulatory and quality teams as new capabilities are developed and transitioned into production environments.

The Associate Director of Production and Process Improvement will role will work closely with BCLs new cell factory that will span the full experimental and analytical pipelinefrom cell culture and genetic perturbation through singlecell sequencing and bioinformatics. The ideal candidate will have a deep understanding of functional genomics be comfortable working crossfunctionally with both wet and dry lab teams and be excited to innovate at the intersection of CRISPR singlecell biology and highthroughput screening.

Roles and Responsibilities:

Brainstorming design plan and execute highthroughput PerturbSeq experiments across diverse cell types and biological systems.
Develop and optimize protocols for CRISPRbased perturbations cell culture singlecell RNAseq and library preparation.
Lead development for improved scalability throughput and data fidelity.
Work with data science teams to analyze PerturbSeq data and derive actionable insights.
Evaluate validate and help implement computational pipelines and analytical tools for singlecell and perturbation data
Drive experimental strategy and innovation for new R&D directions and platform improvements.
Mentor team members and process development associates.
Evaluate and implement emerging technologies in functional genomics singlecell biology multiomics and automation.
Collaborate crossfunctionally with multiple Broad teams to align with platform goals.
Potentially manage up to 5 direct reports

Qualifications:

MS/PhD in a related field or 10 years of related experience. Experience managing teams.
Handson experience with CRISPRbased perturbation methods singlecell RNAseq and cell culture (including primary or stem cells).
Strong understanding of library preparation pooled screening design and sequencing workflows.
Familiarity with data analysis pipelines for singlecell data.
Track record of innovation and problemsolving in complex experimental systems.
Comfortable managing multiple projects timelines and priorities.
Excellent communication skills and a collaborative proactive mindset

Bonus Qualifications:

Experience with PerturbSeq CROPseq or other pooled screening modalities.
Prior leadership or team management experience.
Coding skills (e.g. Python R bash) and experience working with bioinformatics tools.
Experience with automation or highthroughput liquid handling platforms.

Required Experience:

Director

Employment Type

Full Time

Company Industry

Key Skills

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About Company

Broad Institute

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