Scientist Emerging Target Biology Immunology
Scientist Emerging Target Biology Immunology
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
Job Description
The Role
The Scientist will be a broad ranging laboratorybased role and will help to expand our Emerging Target Biology Team. The role will bring additional cellbased functional screening and immunology expertise to triage lead antibody candidates derived from Alchemabs platform technology. Working closely within the Research team they will build projectrelevant inhouse capability for a wide variety of cellbased assays. They will utilise in vitro assay development skills and demonstrate expertise with cell lines and primary cells to study antibody function in disease relevant assays. In addition the successful candidate will work to improve the workflows surrounding the capture analysis and recording of data in partnership with the Alchemab Tech team.
The role is based in Cambridge UK.
Responsibilities
- Independently design perform and interpretcellbased functional assays
- Assay examples may include: Cell viability and proliferation Apoptosis transwell migration and invasion assay Tcell Activation and Proliferation (including antigen recall) Mixed Lymphocyte Reaction (MLR) AntibodyDependent Cellular Cytotoxicity (ADCC) ComplementDependent Cytotoxicity (CDC)
- Techniques may include: Cell culture Western blots ELISAs MSD Flow cytometry (using multi colour panels) Immunocytochemistry and Imaging transcriptomic analysis including qPCR
- Cell types may include immortalized and primary cells (including cells derived from human blood samples) in monocultures and 3D formats
- Software may include: FlowJo Graphpad Prism Benchling Image J
- Work with team to design analyse and interpret results from in vivo experiments
- Assist other areas of business as needed including Neuroscience and Oncology laboratory work
- Work collaboratively with the Scientific team and with external research groups and partners
- Work to improve the efficiency of data capture analysis and recording in partnership with the Alchemab Tech team.
- Communicate efficiently interpret and share results to different audiences.
- Maintain accurate and uptodate electronic laboratory notebook records
- Maintain assigned laboratory equipment and/or duties
- Perform all work demonstrating due care and attention to all health and safety and COSHH regulations and Human Tissue Act records where required
- Work closely with the scientific leadership team to review targets and help build Alchemabs target portfolio
Experience & Requirements
Essential
- A PhD in a relevant scientific discipline (or industry equivalent)
- An ability to work independently developing running and troubleshooting new scientific techniques and experimental protocols and ability to share results in clear manner
- A high attention to detail in planning and performing assays for example proactive inclusion of appropriate positive and negative controls
- Strong background in cell biology including priorexperience performing and designing complex cell and biochemical functional assays with immunological readouts on primary cells including primary PBMCs and/or T cells and expertise in flow cytometry
- An ambition to work with the Alchemab team to build a transformative company
- A team player who proactively and directly communicates and collaborates with other team members
Desirable
- Experience in Immunology target review
- Experience in an industrial drug discovery environment
- Experience of working in a collaborative space for example with CROs or independent academic groups
NOTE: This job description is not intended to be all inclusive. Employees may perform other related duties as negotiated to meet the ongoing needs of the organisation.
Note to recruitment agencies: we are not looking for assistance at this stage so please contact the HR department only at if you think you can help in the future.
Required Experience:
Senior IC
Employment Type
Full-Time
