Structural Bioinformatics Scientist London
Structural Bioinformatics Scientist London
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Job Description
Structural Bioinformatics Scientist London
We are here to advance human health by reimagining drug discovery with the power and pace of artificial intelligence.
The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured by better and faster drug discovery.
Our values exist in service of that future. We think theyll help us bring it closer too.
Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals while being a part of an inspiring and collaborative culture.
The world we want tomorrow is the one were building today. It starts with the culture at this company. It starts with you.
About Iso
Isomorphic Labs (IsoLabs) was founded in 2021 and is led by Sir Demis Hassabis. Our aim is to usher in a new era of biomedical breakthroughs and find cures for some of humanitys devastating diseases.
Our foundations are built on the success of Google DeepMinds AlphaFold but we didnt stop there! We are continuing to develop and implement stateoftheart technologies as we move towards our goal of dramatically accelerating and improving the process of designing and bringing new medicines to patients.
We have built a worldleading drug design engine comprising foundational AI models that are capable of working across multiple therapeutic areas and drug modalities. The company is continually innovating on model architecture and developing cuttingedge capabilities to advance rational drug design.
Your impact
You will be joining as a core member of the Structural Bioinformatics team focused on tackling the most challenging drug discovery problems at proteomewide scales.
As a member of the Structural Bioinformatics team you will be responsible for the application and development of applied ML methods leveraging our stateoftheart platform to characterise and interrogate the proteome unlike ever before. The scope of work spans the study of protein folds protein function proteinprotein and proteinligand interactions with the goal of designing novel therapeutics. You will design and execute on bold strategies to answer questions around druggability selectivity and toxicity spanning all protein classes.
Structural Bioinformatics will be a multidisciplinary team working alongside worldclass ML Engineering Product and Drug Discovery teams. You will collaborate to deliver scientific expertise and strategic direction to drive the development of our platform and apply it to unsolved drug design problems.
If you are a skilled and ambitious scientist looking to take the next step in your career joining Isomorphic Labs now will catapult you out of your comfort zone and provide you with an amazing opportunity for personal growth and technical development.
What you will do
- Combine your expertise in bioinformatics/cheminformatics and structural biology with internal stateoftheart ML models and representations to create creative solutions for the identification of novel drug targets exploring new protein functions selectivity and characterising ligandability.
- Design robust in silico experiments that evaluate platform performance at proteomewide scales.
- Work closely with the Exploratory Sciences team to explore emerging chemical biology datasets and new modalities with the potential of converting this work into new portfolio projects.
- Collaborate both internally and with third party organisations interacting within multidisciplinary teams to support datadriven delivery of high quality scientific solutions to complex technical problems.
- Analyse and interpret data from active drug discovery projects.
- Prepare detailed scientific proposals presentations and reports to support new and ongoing programs.
- Embrace and champion our culture of inclusion and continuous professional development.
Skills and qualifications
Essential:
- Experience developing or working with ML models and tools pertinent to drug discovery.
- Experience working with protein structures peptides and/or small molecule data.
- Ph.D in structural biology bioinformatics computational biology chemistry cheminformatics or a related technical field or equivalent experience.
- Broad knowledge of the current bioinformatics computational biology computational chemistry cheminformatics and ML methods.
- Strong programming skills in Python.
- Strong analytical and creative problemsolving skills.
- Ability to work independently and as part of a team.
Nice to have:
- Broad knowledge of the human proteome including protein function protein folds and experimental and computational methods used to characterise proteins.
- Direct experience of working in pharma or biotech companies on drug discovery projects.
- Experience of contributing to StructureBased Drug Design problems.
- Track record of authorship of relevant scientific literature.
Culture and values
We are guided by our shared values. Its not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.
Thoughtful
Thoughtful at Iso is about curiosity creativity and care. It is about good people doing good rigorous and futuremaking science every single day.
Brave
Brave at Iso is about fearlessness but its also about initiative and integrity. The scale of the challenge demands nothing less.
Determined
Determined at Iso is the way we pursue our goal. Its a confidence in our hypothesis as well as the urgency and agility needed to deliver on it. Because disease wont wait so neither should we.
Together
Together at Iso is about connection collaboration across fields and catalytic relationships. Its knowing that transformation is a group project and remembering that what were doing will have a real impact on real people everywhere.
Creating an extraordinary company
We believe that to be successful we need a team with a range of skills and talents. Were building an environment where collaboration is fundamental learning is shared and every employee feels supported and able to thrive. We value unique experiences knowledge backgrounds and perspectives and harness these qualities to create extraordinary impact.
We are committed to equal employment opportunities regardless of sex race religion or belief ethnic or national origin disability age citizenship marital domestic or civil partnership status sexual orientation gender identity pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation please do not hesitate to let us know.
Hybrid working
Its hugely important for us to share knowledge and build strong relationships with each other and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model and would require you to be able to come into the office 3 days a week (currently Tuesday Wednesday and one other day depending on which team youre in). If you have additional needs that would prevent you from following this hybrid approach wed be happy to talk through these if youre selected for an initial screening call.
Please note that when you submit an application your data will be processed in line with our .
Employment Type
Full Time
