Scientist Computational Biology
Scientist Computational Biology
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Job Description
Colossal is seeking a talented computational biologist with strong analytical skills to tackle challenging genotypetophenotype questions. The successful candidate will collaborate with scientists and engineers to design and perform bioinformatics analyses and integrate genomic epigenomic transcriptomic and proteomic datasets to support Colossal Biosciences deextinction efforts. The candidate must have experience in bioinformatics computational biology or comparative genomics.
Preference will be given to candidates with a PhD who have experience developing genotypetophenotype AI/ML methods that integrate across data sets particularly applying diverse data (genomics epigenomics transcriptomics proteomics) alongside functional annotations and ontologies to datasparse or nonmodel organisms.
**This position will be based out of Dallas TX office or remote from within the United States with 12 yearly site visits.
Duties and Responsibilities:
- Run data analysis with biological data
- Run comparative functional and statistical genomics analysis
- Develop new tools in R/Python for data analysis and visualization
- Prepare reports and presentations to communicate findings to wetbench biologists
Required Skills and Abilities:
- Two years of bioinformatics experience in the following areas: Comparative Genomics Functional Genomics / MultiOmics Molecular Evolution or Applied AI in Genomics.
- Experience in the development of models to predict biological results or gene function including variant detection functional predictions and genotype/phenotype relationships.
- Demonstrated 2 years of experience with scripting languages including but not limited to: Python R Perl Ruby Java and BASH.
- Ability to write and run custom bioinformatics scripts using existing published tools and occasionally tools developed to summarize the results in a digestible manner and deliver the information using established reporting procedures.
- Proficiency with handling largescale genomic data in an HPC (SGE SLURM PBS) Linux and/or cloud environment (e.g. AWS Google Cloud Azure).
- Experience in using GIT version control software and maintaining welldocumented reproducible notebooks and workflows.
- Ability to design and maintain databases (MySQL PostgreSQL MongoDB) and connect with visual platforms to curate and share data with nonbioinformatics team members.
Preferred Skills and Abilities:
- Developing or implementing AI/ML frameworks and systems biology networks (e.g. interpretable aka visible deep neural networks like GenNet) for genotypetophenotype and functional predictions
- Calling germline and somatic sequence variants from highcoverage WGS lowcoverage WGS with imputation and sequencing libraries from degraded or ancient DNA
- Performing evolutionary and statistical genomics analyses including genomewide scans for evolutionary signatures and selective sweeps and population genetics analysis (e.g. runs of homozygosity and association mapping)
- Constructing interpreting and utilizing pangenome graphs
- Statistical planning and collaboration with laboratory scientists on designing wellpowered experiments to generate useful multiomics data sets
- Understanding of precision gene editing technologies like CRISPR/Cas9 systems
Education and Experience:
- Masters with 2 years of experience or PhD in quantitative or basic science (computer science computational biology bioinformatics chemistry physics or mathematics preferred) is required
What Colossal Offers You:
- Medical dental and vision coverage
- Unlimited PTO and company holidays so you can rest and recharge
- Flexible spending accounts (FSA)
- Company matched 401k retirement plan
- Paid parental leave up to 12 weeks
- Education reimbursement
- An opportunity to help us return the Earth to a healthier state
The team at Colossal is committed colorful passionate intelligent collaborative creative experienced scientific and worldclass. That sounds like a lot to fit into one building. Thats why we are spread out in several locations that include laboratories test facilities academic institutions libraries and offices.
Through it all however we maintain a culture of positivity hope happiness and belief that were doing something big. Something Colossal.
Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive.
Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no preexisting agreement is in place. We handle most recruitment inhouse.
Colossal is proud to be named a Best Place to Work by BuiltIn for 3 years in a row across multiple categories inand 2025:
- #1 on the 50 Best Startups to Work For in Dallas in 2023!
- 100 Best Midsize Places to Work in Dallas in 2024 & 2025
- 100 Best Places to Work in Dallas TX (All Size Employers) in 2024 & 2025
Great Place to Work Certification Page
Employment Type
Full Time
