Postdoctoral Research Associate - Structural Biology
Postdoctoral Research Associate - Structural Biology
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Salary Not Disclosed
1 Vacancy
Job Description
The Blanchard laboratory in the Department of Structural Biology is seeking a highly motivated Postdoctoral Fellow with experience in protein and membrane protein biochemistry to join a newly funded GPCR collaborative project to investigate the structural dynamics of GPCRs and their signaling partners using biophysical methods including singlemolecule FRET (smFRET).
The ideal candidate would be a recent PhD graduate with a demonstrated capability to propose new hypotheses based on scientific literature design experiments and interpret results in a mechanistic framework. Our highly interdisciplinary collaborative missiondriven environment requires a creative teamoriented individual who will ensure highquality operations and share our vision to successfully pursue impactful scientific advances.
Successful candidates should have demonstrated competencies in the following areas:
Capability to express purify and biochemically characterize membrane proteins in mammalian and/or insect cell culture.
Prior experience with singlemolecule biophysical techniques GPCR biology or quantitative modeling.
Significant contribution towards peerreviewed research articles in related scientific subject(s).
Excellent communication and presentation skills and ability to prepare highquality manuscripts of findings for publication.
Selected Publications:
GPCRmediated arrestin activation deconvoluted with singlemolecule precision.
Singlemolecule analysis of ligand efficacy in 2ARGprotein activation.
Quantifying secondary transport at singlemolecule resolution
CFTR function pathology and pharmacology at singlemolecule resolution
Responsibilities:
Design and perform biochemical and biophysical experiments to investigate structuredynamicsfunction relationships of various integral membrane proteins or membraneassociated proteins involved in GPCRmediated signaling pathways.
Protein purification sitespecific fluorophore labeling and biochemical/functional characterization of GPCRs Gproteins arrestins and other signaling proteins.
Perform singlemolecule fluorescence (smFRET) imaging of labeled signaling molecules with guidance and training from technical experts in the field analyze smFRET data and interpret the results in mechanistic quantitative frameworks with guidance and training from technical experts in the field.
Work independently leading a project from hypothesis to highquality oral presentations and publications.
Collaborate with an interdisciplinary group of researchers as part of a multiinstitutional collaborative including presentations to a broad audience.
Train and mentor of graduate students postdocs and visiting scientists.
Instructs other staff in basic laboratory techniques and procedures.
Minimum Education:
Ph.D. in life sciences or other physical sciences required.
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Required Experience:
IC
Employment Type
Full-Time
