Roche Postdoctoral Fellowship RPF on Alveolar Regeneration in Homeostasis and Inflammatory Disease
Roche Postdoctoral Fellowship RPF on Alveolar Regeneration in Homeostasis and Inflammatory Disease
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Job Description
At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.
The Position
At Roche we believe its urgent to deliver medical solutions right now even as we develop innovations for the future. We are passionate about transforming patients lives and we are fearless in both decision and action. And we believe that good business means a better world.
That is why we come to work every single day. We commit ourselves to scientific rigor unassailable ethics and access to medical innovations for all. We do this today to build a better tomorrow.
The Position
We are seeking a highly motivated postdoctoral fellow to join the Immunology Discovery group of the Cardiovascular Metabolism and Immunology Department. The successful candidate will investigate the molecular pathways that drive the regeneration and function of human alveolar cells in homeostasis and under inflammatory disease conditions. Research will focus on targeting Wnt and other signaling pathways using novel pharmacologic modulators to uncover novel synergistic interactions. The overarching goal is to gain a deeper understanding of the fundamental processes of lung regeneration in the context of disease and to devise novel therapeutic strategies.
Key Responsibilities
Highthroughput culture of human alveolar and airway organoids
Investigating the impact of diseaserelevant perturbations to identify conditions that recapitulate the disease molecular state
Phenotypic and molecular characterization using techniques such as immunofluorescence flow cytometry and singlecell RNAsequencing (scRNAseq)
Using pharmacological modulators to understand pathways involved in alveolar cell regeneration and differentiation
Investigating how modulating the identified signaling pathways can impact the function of alveolar progenitor cells under disease conditions
Qualifications
PhD in Molecular Biology Cell Biology Developmental Biology Pharmacology or a related field
To be eligible for a Roche Postdoctoral Fellowship you must be within the first four years of completing your PhD in a relevant field at the start of the project
Strong background in cell signaling particularly Wnt pathways and experience with organoid culture systems
Proficiency in highthroughput screening techniques and data analysis is desired
Experience with genetic engineering and iPSC technology is desirable
Proficiency in computational analysis and data interpretation is highly desired
Excellent problemsolving skills and the ability to work independently and collaboratively in a multidisciplinary team
This position is sponsored by the Roche Postdoctoral Fellowship Programme.
The RPF Programme has the ambition to build and maintain the Scientific Leadership of the future and to provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers and leading academic research groups from around the world. One of the key aims is to advance basic science and technologies that will be published in toprated peerreviewed scientific journals if necessary preceded by priority patent applications.
More information about the RPF Program can be found here.
The duration of the RPF project is initially set for two years with the possibility of extension for a third year. You will be based in Basel Switzerland.
The start date of this fellowship is on availability. Please clearly indicate your preferred starting date in your motivation letter.
All applications always need to include:
your CV
a motivation letter
and a publication list.
Do you know what Roche stands for Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds perspectives and skills. The more inclusive we are the better our work will be.
If you still have questions then please check our FAQs and videos here.
Who we are
A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver lifechanging healthcare solutions that make a global impact.
Lets build a healthier future together.
Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10700 employees from over 100 countries come together at our Basel/Kaiseraugst site which is one of Roches largest sites. Read more.
Besides extensive development and training opportunities we offer flexible working options 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as childcare facilities medical services restaurants and cafeterias as well as various employee events.
Roche is an Equal Opportunity Employer.
Employment Type
Full-Time
