Scientist Analytical Operations

Were here for one reason and one reason only to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. Weve made incredible scientific breakthroughs and our pioneering personalized CAR Tcell therapies have changed the paradigm. But were not finished yet.

Join Kite as we make even bigger advances in cancer therapies and help shape where our business and medical science goes next.

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Job Description

Kites Attributes Sciences team is seeking a highly motivated Research Scientist with a strong background in virology and/or cancer biology to elucidate the structure and function of Kites gene editing platforms (viral and nonviral modalities) for developing cell therapy products.

In this role the ideal candidate will be responsible for independently designing planning and executing studies to enhance our understanding of vector quality attributes. The successful candidate will work crossfunctionally to identify opportunities for continuous process improvement for viral vector manufacturing and nonviral gene editing modalities. The scope of this role will evolve and expand over time to include mentoring junior team members and working with key stakeholders to identify new technologies and opportunities for continuous process & product improvement.

Responsibilities include (but are not limited to):

• Develop capabilities for inhouse biophysical characterization of viral vectors (e.g. Dynamic Light Scattering SedimentationVelocity Analytical UltraCentrifugation Nanoparticle Tracking Analysis) to enhance viral vector product understanding.

• Lead the design of functional assays to assess viral vector fitness and mechanism of action on novel cell therapy drug product development.

• Perform multicolor flow cytometry and virometry to interrogate immunophenotype cell health and viral vector attributes (e.g. viral titer potency and purity).

• Contribute to development of innovative approaches to evaluate vector genomic integrity integration sites and host cell proteins immunogenecity via omics approaches e.g. scRNAseq Long read sequencing and mass spectrometry.

• Play a key role in crossfunctional intiatives aimed at designing studies that yield characterization data to mitigate potential risks to product quality.

• Function as a key contributor to Analytical Development knowledge by remaining up to date on scientific literature and the newest developments in relevant fields.

• Author review and edit technical documents such as SOPs and/or reports.

• Function independently in nonroutine development activities and project goals.

• Maintain accurate documentation of experiments in ELN and reports.

• Present findings at internal meetings and/or contribute to the preparation of filling and patent applications.

• Provide technical guidance and mentorship to junior staff regarding concepts of virology immunology and cell biology.

Basic Qualifications:

• Masters Degree and Five Years Experience; OR

• Bachelors Degree and Seven Years Experience; OR

• Associates Degree and Nine Years Experience; OR

• High School Degree and Eleven Years Experience

Preferred Qualifications:

• Advanced knowledge of virology cell biology and/or immunology preferred.

• Hands on experience with multicolor flow cytometry and flow cytometry data analysis (FACSDiva FlowJo)

• Experience with highthroughput screening methods for impurities profiling and biophysical characterization techniques (e.g. DLS SVAUC NTA FlowCam Nano)

• Prior experience with ddPCR ELISA MSD or Luminexbased assays is a plus.

• Proficiency in data analysis software (e.g. FlowJo JMP Prism Microsoft office).

• Highly collaborative with excellent interpersonal verbal and written communication skills.

• Evidence of high level of scientific expertise demonstrated through scientific publications literature review and scientific conference participation is preferred.

• Selfmotivated organized and detailoriented with demonstrated ability to work efficiently as part of a team.

• Ability to think critically and demonstrate troubleshooting and problemsolving skills.

• Comfortable in a dynamic fastpaced environment with minimal direction.

• Agile mindset and ability to adjust workload based upon changing priorities.

For additional benefits information visit:

Eligible employees may participate in benefit plans subject to the terms and conditions of the applicable plans.

Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid longterm durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune systems ability to recognize and tumors. Kite is based in Santa Monica CA. For more information on Kite please visit . Sign up to follow @KitePharma on Twitter at jobs in the United States:

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